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Understanding the detailed properties and synthesis pathways of chemical intermediates is crucial for researchers and manufacturers alike. 5-Methylquinoline (CAS 7661-55-4) is one such compound that warrants attention due to its versatility in organic synthesis. This article provides a deep dive into its characteristics, common production methods, and practical considerations for sourcing this essential chemical.
Physical and Chemical Properties:
5-Methylquinoline, with the molecular formula C10H9N and a molecular weight of approximately 143.19 g/mol, is a heterocyclic aromatic compound. Its appearance is often described as a brown to black liquid, although some sources indicate a light yellow oily liquid depending on purity and handling. Key physical properties include a melting point around 19°C, meaning it can be a solid or liquid at room temperature depending on ambient conditions. Its boiling point is notable, typically around 262.7°C at atmospheric pressure. The density is approximately 1.0832 g/cm³. It exhibits miscibility with ethanol and ether, is soluble in benzene, and shows slight solubility in water.
Synthesis Routes:
The synthesis of 5-Methylquinoline can be achieved through several established organic chemistry routes. A common method involves reacting m-amino-p-toluonitrile, glycerol, and m-nitrobenzene sulfonate in an acidic environment, often referred to as a variation of the Skraup synthesis or Friedländer synthesis principles. These methods leverage readily available starting materials to construct the quinoline ring system with the desired methyl substitution. For industrial-scale production, optimization of reaction conditions, catalyst selection, and purification processes are key to achieving high yields and purity.
Applications:
The primary utility of 5-Methylquinoline lies in its role as a chemical intermediate. It is extensively used in the synthesis of:
Global Supply and Procurement:
For businesses looking to buy 5-Methylquinoline, reliable sourcing is critical. Manufacturers in China, such as NINGBO INNO PHARMCHEM CO.,LTD., are prominent global suppliers, offering this intermediate with high purity (typically 97% min). When sourcing, it is essential to request detailed specifications, Certificates of Analysis (CoA), and Material Safety Data Sheets (MSDS). Obtaining multiple quotes from different suppliers can help ensure competitive prices and favorable terms. For bulk purchases, discussing lead times, packaging options, and logistics with your chosen supplier is a standard practice to guarantee a smooth procurement process.
In conclusion, 5-Methylquinoline is a foundational intermediate whose properties and applications make it indispensable in several key industries. Understanding its synthesis and sourcing efficiently allows companies to leverage its potential for innovation and production.
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