6-METHOXY-2,3-DIOXYINDOLE (CAS: 52351-75-4): A Versatile Indole Derivative for Advanced Chemical Synthesis

6-METHOXY-2,3-DIOXYINDOLE, also widely known by its synonyms such as 6-Methoxyisatin or 6-Methoxy-1H-indole-2,3-dione, stands as a pivotal chemical compound in various synthesis pathways. With the Chemical Abstracts Service (CAS) number 52351-75-4, this organic intermediate is characterized by its precise molecular formula, C9H7NO3, and a molecular weight of 177.16 g/mol. Its unique indole structure, featuring a methoxy group at the 6-position and a diketone functionality at the 2 and 3 positions, contributes to its distinctive chemical reactivity and broad applicability.

Physical and chemical characterization reveals that 6-METHOXY-2,3-DIOXYINDOLE typically presents as a yellow powder. It boasts a melting point in the range of 229-230 °C, indicating its stable crystalline structure. The compound's density is approximately 1.346±0.06 g/cm3, and it exhibits good solubility in various organic solvents, a property crucial for its diverse applications in chemical reactions. For optimal preservation of its high purity, storage in a dark place under an inert atmosphere at room temperature is recommended, ensuring its integrity for long-term use in sensitive chemical processes.

The significance of 6-METHOXY-2,3-DIOXYINDOLE primarily lies in its role as an indispensable intermediate in the pharmaceutical and fine chemical industries. It serves as a fundamental building block for the synthesis of a wide array of natural products and complex active compounds. One notable application involves its use as a starting material in the synthesis of spirodol alkaloids, such as strychnofoline. These alkaloids have garnered significant scientific interest due to their promising biological activities, including demonstrated anti-tumor properties, highlighting the compound's indirect contribution to the development of novel therapeutic agents.

Furthermore, derivatives of 6-METHOXY-2,3-DIOXYINDOLE have found utility in cutting-edge research. For instance, NMP6, a compound derived from 6-Methoxyisatin, functions as a highly effective fluorescent probe for CB2 receptors. This capability is invaluable in visualizing immune cell receptor binding, offering researchers a powerful tool for studying immune responses and related cellular mechanisms. Beyond specific syntheses, the compound’s inherent structure also endows it with potential biological activities, such as antioxidant and anti-inflammatory properties, making it a subject of ongoing investigation for various medicinal chemistry applications. Its versatility as a chemical scaffold makes it highly adaptable for numerous modifications, which can lead to the discovery and development of new molecules with enhanced functionalities.

NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier of high-quality 6-METHOXY-2,3-DIOXYINDOLE (CAS: 52351-75-4). We are committed to providing chemical products that meet stringent quality standards, ensuring reliability and performance for all our clients. Our extensive experience and advanced manufacturing capabilities allow us to offer this critical intermediate in various packaging sizes, from gram-scale quantities for research and development to bulk packages for industrial production. For those looking to buy 6-METHOXY-2,3-DIOXYINDOLE, our competitive price structure and dedication to customer satisfaction make us an ideal partner. We maintain a robust inventory to ensure prompt delivery and can provide detailed product specifications and technical support. To inquire about specific quantities or to purchase this essential chemical intermediate, please contact us directly. We strive to be your trusted partner in chemical sourcing, delivering both value and excellence.