Understanding the complex mechanisms of DNA repair is fundamental to advancing our knowledge in genetics, oncology, and various disease states. For researchers focused on these critical areas, 6-O-Benzylguanine (CAS 19916-73-5) is an indispensable pharmaceutical intermediate and research chemical. As a leading manufacturer and supplier, we are dedicated to providing scientists with this high-quality compound to facilitate their groundbreaking work.

What is 6-O-Benzylguanine?

6-O-Benzylguanine (O6-BG) is a purine analog that plays a significant role in cellular biology due to its potent inhibitory effect on the enzyme O6-alkylguanine-DNA alkyltransferase (MGMT). MGMT is a key player in DNA repair, specifically responsible for removing alkyl groups from the O6 position of guanine, a common type of DNA damage that can lead to mutations and cell death.

By acting as a suicide substrate for MGMT, 6-O-Benzylguanine effectively and irreversibly inactivates the enzyme. This unique property makes it a powerful tool for researchers seeking to study the consequences of inhibited DNA repair, particularly in the context of cancer and its treatment.

Key Applications in DNA Repair Research:

• Investigating MGMT Function: Researchers use O6-BG to block MGMT activity, allowing them to study the enzyme's role in protecting cells from DNA damage and its implications in drug resistance.
• Enhancing Chemotherapy Efficacy: In cancer research, O6-BG is used to sensitize tumor cells to alkylating chemotherapy agents, improving their therapeutic potential. This is crucial for overcoming resistance mechanisms.
• Cellular Response to Damage: By creating a state of functional MGMT deficiency, O6-BG helps scientists understand how cells respond to unrepaired DNA lesions, leading to insights into mutagenesis and apoptosis.
• Biomarker Development: Its specific interaction with MGMT makes it a valuable compound in developing assays and probes to measure MGMT levels in biological samples.

Sourcing High-Quality 6-O-Benzylguanine (CAS 19916-73-5)

When procuring 6-O-Benzylguanine for your research, it is crucial to partner with a reliable manufacturer and supplier. We understand that consistency, purity, and timely delivery are paramount for your scientific endeavors. Our commitment as a manufacturer in China ensures that you receive:

• High-Purity Product: Our 6-O-Benzylguanine is produced to high purity standards (typically 97% min.), ensuring reliable and reproducible results in your experiments.
• Competitive Pricing: We offer this essential pharmaceutical intermediate at competitive prices, making advanced research more accessible.
• Secure Supply Chain: As a leading supplier, we maintain a stable supply, ensuring you can buy 6-O-Benzylguanine when you need it for your ongoing projects.
• Comprehensive Documentation: We provide detailed specifications, CoA, and MSDS to support your research and procurement needs.

By choosing us as your supplier, you gain access to a critical research chemical that fuels advancements in understanding DNA repair and developing novel therapeutic strategies. Whether you are in academia or the pharmaceutical industry, our 6-O-Benzylguanine is engineered to meet your highest standards.

Contact us today to request a quote and to ensure a consistent supply of high-quality 6-O-Benzylguanine (CAS 19916-73-5) for your vital DNA repair research.