For chemists and researchers engaged in fine chemical synthesis, understanding the detailed properties and synthesis pathways of key intermediates is crucial. 7-Bromo-1H-indazole (CAS 53857-58-2) is a prominent example, valued for its structural features and reactivity. This article provides an in-depth look at its chemical characteristics and synthesis, alongside guidance for procurement professionals seeking to buy this compound from a reliable source.

Chemical Profile of 7-Bromo-1H-indazole

7-Bromo-1H-indazole is typically supplied as a solid, often appearing as a pale yellow or off-white powder. Its molecular formula is C7H5BrN2, with a molecular weight of approximately 197.03 g/mol. Key physical properties often cited include a melting point in the range of 123-130°C, and a density of around 1.77 g/cm³. The presence of the bromine atom on the indazole ring makes it an excellent substrate for various organic transformations, most notably palladium-catalyzed cross-coupling reactions such as Suzuki, Sonogashira, and Buchwald-Hartwig couplings. These reactions are fundamental in constructing complex organic molecules, including advanced pharmaceuticals and materials.

Synthesis of 7-Bromo-1H-indazole

The synthesis of 7-Bromo-1H-indazole often involves multi-step processes starting from readily available precursors. One common approach involves the Sandmeyer reaction on a suitably substituted aminoindazole. For example, starting from 7-aminoindazole, diazotization followed by treatment with a copper(I) bromide source in hydrobromic acid can yield the desired brominated product. Another reported method may involve the cyclization of substituted phenylhydrazines or related precursors, followed by bromination at the appropriate position. Yields can vary depending on the specific reaction conditions and purification methods employed. As a dedicated chemical supplier, we ensure that our 7-Bromo-1H-indazole is synthesized under controlled conditions to guarantee high purity and consistent quality, which is vital for its application in demanding research and industrial processes.

Procurement: Finding a Trustworthy Supplier in China

For researchers and procurement specialists, obtaining 7-Bromo-1H-indazole with high purity (often specified as ≥97% or ≥98%) is a primary concern. When looking to buy this compound, it is essential to partner with a reputable manufacturer and supplier who can provide comprehensive technical documentation, including Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS). As a leading chemical supplier in China, we are equipped to meet these requirements. We offer competitive pricing and reliable global delivery for 7-Bromo-1H-indazole, supporting your R&D endeavors. We encourage inquiries regarding pricing, bulk orders, and any specific technical queries you may have.

Key considerations when purchasing:

• CAS Number Verification: Always confirm the CAS number (53857-58-2) to ensure you are acquiring the correct isomer.
• Purity Standards: Prioritize suppliers offering ≥97% purity for critical synthesis applications.
• Documentation: Request CoA, MSDS, and any relevant technical data.
• Supplier Reliability: Choose manufacturers with a proven history of quality and service.
• Quantity Flexibility: Ensure the supplier can accommodate both small research quantities and larger bulk orders.

In summary, 7-Bromo-1H-indazole is a cornerstone intermediate for many synthetic chemistry projects. By understanding its properties and synthesis, and by partnering with a dependable China-based manufacturer and supplier like ourselves, researchers can effectively secure the materials needed for their critical work. Contact us today to get a quote or to learn more about how we can support your chemical sourcing needs.