For chemical professionals and researchers, understanding the precise technical specifications of chemical intermediates is crucial for successful synthesis and product development. 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one, identified by CAS number 160129-45-3, is a compound that warrants close attention due to its utility in advanced organic synthesis, particularly within the pharmaceutical sector. This article provides an overview of its key technical attributes and guides you on how to source it effectively.

Key Technical Attributes of the Intermediate

Chemical Identity:

• Chemical Name: 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one
• CAS Number: 160129-45-3
• Synonyms: 7-Chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one, 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one, 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
• Molecular Formula: C10H10ClNO
• Molecular Weight: 195.65 g/mol

Physical and Chemical Properties:

• Appearance: Yellow crystalline powder
• Melting Range: 95-105 °C (reported values vary slightly, e.g., 103-104°C)
• Purity (Assay by HPLC): Typically ≥98.0% or ≥99.0%
• Loss on Drying: ≤0.5%
• Related Compounds: ≤0.5%
• Density: ~1.2 g/cm³
• Boiling Point: ~356.5 °C at 760 mmHg
• Flash Point: ~169.4 °C

Primary Application: Pharmaceutical Synthesis

The most significant application for 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one is its critical role as an intermediate in the synthesis of Tolvaptan. Tolvaptan is a vital pharmaceutical agent used to treat conditions characterized by fluid overload and electrolyte imbalances. The demand for high-purity intermediates like this compound is driven by the pharmaceutical industry's need for reliable building blocks in the API manufacturing process. Researchers and bulk purchasers are constantly seeking suppliers that can deliver this specific chemical with guaranteed quality.

Sourcing Strategies and Supplier Considerations

When looking to purchase 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one, it is essential to partner with reputable chemical manufacturers and suppliers. Key considerations include:

• Quality Control: Ensure the supplier provides comprehensive documentation, especially a Certificate of Analysis (CoA), verifying the purity and physical characteristics.
• Reliable Supply: Partner with manufacturers who can offer a consistent and stable supply, meeting your production schedules and research timelines.
• Competitive Pricing: Obtain quotes from multiple suppliers, especially for bulk orders. Look for manufacturers in regions like China that often provide cost-effective solutions for high-quality chemicals.
• Customer Service: A responsive supplier with good technical support can streamline the purchasing process and address any queries promptly.

Conclusion

7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one is a crucial intermediate for pharmaceutical synthesis. Understanding its detailed technical specifications, from purity levels to physical properties, is vital for procurement and R&D professionals. By diligently sourcing this compound from trusted manufacturers, you can ensure the quality and efficiency of your synthesis processes, particularly for important APIs. If you are looking to buy this chemical intermediate, focus on suppliers that provide detailed specifications and a consistent supply chain.