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7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one: Key Gefitinib Intermediate

7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one (CAS: 199327-61-2) stands as a pivotal pharmaceutical intermediate, essential for the synthesis of Gefitinib. This compound, characterized by its specific molecular structure, plays an indispensable role in the production of a crucial drug used in modern oncology. With a molecular formula of C16H21N3O4 and a molecular weight of 319.36, this white to off-white solid boasts a melting point typically ranging from 233-236 °C, affirming its stability and purity, which are paramount in pharmaceutical applications.


The significance of 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one extends directly to its end-use: the creation of Gefitinib. Gefitinib is renowned as an orally active, selective inhibitor of the epidermal growth factor receptor tyrosine kinase (EGFR-TK). This enzyme is a key player in regulating intracellular signaling pathways that are intrinsically linked to the proliferation and survival of cancer cells. By inhibiting EGFR-TK, Gefitinib acts as a targeted therapy, offering a more precise approach to treating certain cancers, particularly non-small cell lung cancer.


The meticulous synthesis of pharmaceutical products like Gefitinib relies heavily on the quality and consistency of their intermediate compounds. Therefore, the purity and precise specifications of 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one are not merely technical details but fundamental requirements. Any deviation in the chemical properties or composition of this intermediate could directly impact the efficacy, safety, and regulatory compliance of the final drug product. Manufacturers adhere to stringent quality control measures to ensure that every batch meets the highest pharmaceutical standards, providing reliability for subsequent drug synthesis processes.


As a key building block in advanced therapeutic agents, the availability of high-grade 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one is vital for global pharmaceutical supply chains. Reliable sourcing from a reputable manufacturer is crucial for drug developers and generic drug producers aiming for efficient and consistent production. Comprehensive technical documentation, including Material Safety Data Sheets (MSDS) and Certificates of Analysis (COA), further supports safe handling and verifies product integrity. Such detailed information is readily available for those seeking to purchase this essential compound.


For research and development in oncology, or for large-scale pharmaceutical production, securing this intermediate from a trusted supplier is a strategic decision. Pricing for this specialized chemical can vary based on quantity and purity, with competitive rates often available for bulk orders. To explore options to buy 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one, prospective clients are encouraged to inquire directly for current price details and minimum order quantities (MOQ). Ensuring a steady and quality supply of this Gefitinib intermediate contributes significantly to ongoing efforts in cancer treatment and research worldwide.

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