The pharmaceutical industry continually seeks high-quality intermediates to ensure the efficacy and safety of final drug products. Among these crucial compounds, (Z)-2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)pent-2-enoic acid, identified by its CAS number 86978-24-7, stands out as a vital building block. This specific chemical entity plays a pivotal role in the synthesis of advanced pharmaceutical agents, particularly within the realm of antibiotics.

This compound, sometimes referred to by its synonyms such as EATB or BTPA, possesses a precise molecular structure defined by its formula C13H18N2O4S and a molecular weight of 298.36. Physically, it presents as an off-white to white crystalline powder, a testament to its high purity. Key physical and chemical properties include a density of approximately 1.279 g/cm3 and a melting point typically ranging from 159 to 161°C. These characteristics underscore its stability and suitability for complex chemical reactions.

The primary application of 86978-24-7 is its indispensable role as an intermediate in the synthesis of cefcapene pivoxil. Cefcapene pivoxil is a highly effective third-generation oral cephalosporin antibiotic. Cephalosporins are a broad class of beta-lactam antibiotics widely used to treat a variety of bacterial infections, including respiratory tract infections, urinary tract infections, and skin and soft tissue infections. The precise molecular architecture provided by 86978-24-7 is fundamental to achieving the desired stereochemistry and functional groups required for the active pharmaceutical ingredient (API) cefcapene pivoxil, ensuring its therapeutic efficacy and safety profile. Its strategic positioning in the synthesis pathway makes it a critical component for pharmaceutical companies dedicated to producing high-quality antibiotics.

To maintain its excellent chemical integrity and reactivity, 86978-24-7 requires careful handling and storage. It is recommended to store this compound in a cool, ventilated, and dry place, ideally at temperatures between 2-8°C, and kept sealed to prevent degradation. Adherence to these storage guidelines is crucial for preserving its purity, which is consistently maintained at ≥99.0%. This high level of purity is paramount for its use in pharmaceutical synthesis, where even trace impurities can significantly impact the final product's quality and regulatory compliance.

For pharmaceutical companies and research institutions looking to purchase this essential intermediate, securing a reliable supplier is key. A reputable manufacturer will ensure not only the high purity and consistent quality of 86978-24-7 but also provide comprehensive technical support and timely delivery. When considering where to buy, it is advisable to engage with a supplier that offers transparent price structures and has a proven track record in supplying specialty chemicals for API synthesis. Prospective buyers should inquire about packaging options, as it can often be customized to meet specific customer requirements, typically available in 25 kg drums or other suitable quantities. Ensuring the product meets stringent international quality standards is also a vital consideration for global pharmaceutical production. Investing in high-quality 86978-24-7 from a trusted source ultimately contributes to the successful development and production of critical medications like cefcapene pivoxil.