7-Chloro-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid, identified by its Chemical Abstracts Service (CAS) number 877674-77-6, stands as a crucial pharmaceutical intermediate. This advanced compound plays a significant role in the synthesis of vital medicinal substances, particularly within the realm of antibacterial agents. Its unique chemical structure, characterized by the molecular formula C13H20ClNO3 and a molecular weight of 273.76, underpins its specific reactivity and efficacy in various chemical processes.

The physical characteristics of 7-Chloro-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid are essential for its handling and application. It typically presents as a light yellow to off-white powder or solid, known for its hygroscopic nature, necessitating storage in a cool, dry place with the container tightly closed and under an inert atmosphere. Key thermal properties include a melting point ranging from 93 to 97 degrees Celsius, and a predicted boiling point of approximately 504.5 degrees Celsius. With a density of 1.189, this compound exhibits slight solubility in common organic solvents like DMSO and Methanol, making it manageable for specific reaction environments.

The primary and most significant application of 7-Chloro-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid lies in its function as a key intermediate for the synthesis of Cilastatin, a renowned dehydropeptidase I inhibitor. Cilastatin is indispensable in modern medicine, particularly when co-administered with carbapenem antibiotics such as Imipenem. Its role is to prevent the rapid renal metabolism of these antibiotics, thereby enhancing their bioavailability and prolonging their therapeutic effectiveness in treating severe bacterial infections. This makes 877674-77-6 an indispensable building block for developing potent antibacterial adjuncts.

At NINGBO INNO PHARMCHEM CO.,LTD., the production of 7-Chloro-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid adheres to stringent quality control standards. Our product consistently achieves an assay of greater than or equal to 99.0% purity, ensuring its suitability for sensitive pharmaceutical synthesis. Furthermore, the loss on drying is maintained at less than or equal to 0.5%, reflecting the high quality and stability of the material. Each batch undergoes rigorous testing to meet precise specifications, guaranteeing reliability and consistent performance for our clients' demanding applications.

While being a vital chemical intermediate, proper handling and storage of 7-Chloro-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid are paramount. Classified under GHS07 with a 'Warning' signal word, it carries hazard statements such as H317, indicating it may cause an allergic skin reaction. Adherence to precautionary statements, including wearing appropriate protective equipment and ensuring good ventilation, is crucial. Its hygroscopic nature necessitates storage in tightly sealed containers in a cool, dry, and well-ventilated area to maintain product integrity and prevent degradation.

As a dedicated manufacturer and reliable supplier of high-quality pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. is well-positioned to meet the global demand for 7-Chloro-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid (CAS 877674-77-6). We offer flexible packaging options, typically available in 25kg drums, with the capability to customize according to specific customer requirements. For those looking to buy or purchase this crucial intermediate, we provide transparent and competitive price structures based on order volume. Our robust production capacity ensures a consistent and timely supply, making NINGBO INNO PHARMCHEM CO.,LTD. your preferred partner for pharmaceutical raw materials. We invite inquiries for bulk orders or customized solutions, guaranteeing excellent service and product quality.