N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide (CAS 90356-78-8) stands as a pivotal chemical compound in the intricate landscape of pharmaceutical synthesis. Renowned for its critical role, this substance serves as a key intermediate in the production of Bicalutamide (CAS: 90357-06-5), a widely recognized non-steroidal antiandrogen used in the treatment of prostate cancer. Its precise molecular structure and reactivity make it indispensable for achieving the desired purity and efficacy in the final active pharmaceutical ingredient.

The chemical, often referred to by its CAS number 90356-78-8, possesses several synonyms that include Bicalutamide Sulfide, (+/-)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methyl-propanamide, and N-(4-Cyano-3-trifluoromethyl-phenyl)-3-(4-fluoro-phenylsulfanyl)-2-hydroxy-2-methyl-propionamide, among others. These aliases reflect its complex nomenclature and its close association with the drug Bicalutamide. Its molecular formula is C18H14F4N2O2S, and it has a molecular weight of 398.375 g/mol. This specific composition underpins its unique chemical behavior and its suitability for advanced pharmaceutical applications.

Understanding the physical and chemical properties of N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide is crucial for its safe handling, effective storage, and optimal utilization in synthesis. This compound typically appears as a white to off-white powder. Key physical parameters include a density of approximately 1.43 g/cm3 and a melting point ranging from 109-111°C. Its boiling point is estimated around 565.6±50.0 °C at 760 mmHg, indicating its thermal stability under normal atmospheric conditions. The flash point is approximately 295.9±30.1 °C, and its vapor pressure is low, around 0.0±1.6 mmHg at 25°C. The index of refraction stands at 1.585, providing further characterization for analytical purposes.

Quality assurance is paramount for pharmaceutical intermediates. Our specifications for this product ensure high purity and consistency. The appearance is rigorously maintained as a white to off-white powder, with an assay of ≥97.0%. For packaging, it is typically provided in 25 kg/drum, with flexibility to accommodate diverse customer requirements for quantity and packaging solutions. Proper storage is essential to maintain its integrity and extend its shelf life; it should be stored in a cool, ventilated place, away from direct sunlight and incompatible materials, ensuring its stability over time.

Safety considerations are also a vital aspect of handling this chemical. According to GHS classification, N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide may cause an allergic skin reaction (H317) and is toxic to aquatic life with long lasting effects (H411). Precautionary measures include avoiding breathing dust/fume/gas/mist/vapors/spray (P261), ensuring contaminated work clothing is not allowed out of the workplace (P272), and wearing appropriate protective gloves/clothing/eye/face protection (P280). Additionally, release to the environment should be avoided (P273). In case of skin contact, wash with plenty of water (P302+P352) and seek medical help if irritation or rash occurs (P333+P313). Proper disposal of contents/container is necessary in accordance with applicable laws and regulations (P501). Adherence to these guidelines ensures a safe working environment and responsible management of the substance.

The consistent availability of high-quality intermediates like N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide is crucial for the pharmaceutical industry. Its role in Bicalutamide synthesis highlights its importance in the global healthcare supply chain, contributing to the production of vital medications. Companies dedicated to providing reliable chemical solutions play a key part in this ecosystem, ensuring that active pharmaceutical ingredients can be manufactured efficiently and to the highest standards.

For those seeking a dependable manufacturer and supplier of N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide, we offer competitive price options for various order sizes. Whether you are looking to buy for research and development or need to purchase in bulk for commercial production, our dedicated team is ready to assist. We ensure stringent quality control and efficient global logistics to meet your procurement needs. Contact us today for inquiries regarding bulk orders or specific requirements.