Custom Manufacturing, Project Outsourcing, your Trusted Partner from China
The field of oncology has been revolutionized by the advent of targeted therapies, drugs designed to specifically attack cancer cells while minimizing damage to healthy ones. Acalabrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, is a prime example of such an advancement, offering new hope for patients with various B-cell malignancies. The development and large-scale production of Acalabrutinib rely heavily on the consistent supply of high-quality pharmaceutical intermediates, including (2S)-2-(8-Amino-1-Bromoimidazo[1,5-a]Pyrazin-3-yl)-1-Pyrrolidinecarboxylate (CAS 1420478-88-1).
Acalabrutinib works by inhibiting BTK, a key protein in the signaling pathway that promotes the survival and proliferation of malignant B-cells. By blocking this pathway, Acalabrutinib effectively disrupts the growth of cancers like chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and mantle cell lymphoma (MCL). The efficacy of Acalabrutinib in clinical trials and its subsequent approval have made it a cornerstone treatment in hematological oncology.
The journey to producing Acalabrutinib is complex, requiring sophisticated chemical synthesis. The intermediate, (2S)-2-(8-Amino-1-Bromoimidazo[1,5-a]Pyrazin-3-yl)-1-Pyrrolidinecarboxylate, serves as a critical building block, providing a significant portion of the final drug's molecular structure. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. play a pivotal role by providing this intermediate with the required high purity and stereochemical integrity. This ensures that the downstream synthesis of Acalabrutinib is efficient and that the final API meets stringent pharmaceutical standards.
The consistent availability of high-quality intermediates like this is essential for meeting the growing global demand for Acalabrutinib. Pharmaceutical companies rely on trusted suppliers such as NINGBO INNO PHARMCHEM CO.,LTD. to maintain robust supply chains, ensuring that patients have access to these life-saving treatments. The dedication to quality and reliability in intermediate manufacturing directly translates to improved patient outcomes in the fight against cancer.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
