In the dynamic fields of life sciences and pharmaceutical development, specialized chemical compounds play crucial roles. Among these, 10-Acetyl-3,7-dihydroxyphenoxazine, often abbreviated as ADHP (CAS 119171-73-2), stands out for its dual utility as a high-performance fluorogenic probe and a valuable pharmaceutical intermediate. Understanding its properties and applications is key for researchers and manufacturers looking to leverage its capabilities.

The Chemistry and Properties of ADHP

ADHP is a compound characterized by its unique phenoxazine structure, functionalized with acetyl and hydroxyl groups. Its chemical formula is C14H11NO4, and its molecular weight is approximately 257.24 g/mol. One of its most significant features is its role as a fluorogenic substrate. In the presence of enzymes like horseradish peroxidase (HRP) and a source of hydrogen peroxide (H2O2), ADHP undergoes a transformation to produce a highly fluorescent resorufin molecule. This process is highly sensitive and allows for the detection and quantification of H2O2 or enzymatic activity at very low concentrations.

Beyond its application as a probe, ADHP also serves as a critical intermediate in the synthesis of more complex organic molecules. Its reactive functional groups make it amenable to further chemical modifications, essential for building intricate structures required in pharmaceutical research and development.

Key Applications of ADHP

• Biochemical Assays: ADHP is widely employed in biochemical and cellular research for detecting hydrogen peroxide levels. This is particularly important in studying oxidative stress, cellular signaling pathways, and the activity of antioxidant enzymes. Its use enables researchers to gain precise insights into biological processes.
• Enzyme Activity Measurement: As a fluorogenic substrate for peroxidases, ADHP allows for the sensitive measurement of enzyme activity. This is crucial in various diagnostic kits and high-throughput screening platforms used in drug discovery to identify potential enzyme inhibitors or activators.
• Pharmaceutical Intermediate: The structural characteristics of ADHP make it a sought-after building block in the synthesis of pharmaceutical compounds. Its incorporation into larger molecules can impart specific properties or serve as a scaffold for further chemical elaboration. When considering the purchase of ADHP for synthesis, ensuring high purity from a reliable manufacturer is paramount.
• Material Science: While less common, the fluorescent properties of its derivatives may find niche applications in material science, such as in fluorescent labeling or imaging agents.

Where to Buy ADHP (CAS 119171-73-2)

For researchers and companies needing to buy ADHP, sourcing from reputable chemical suppliers is essential. When searching for a supplier, pay close attention to the CAS number (119171-73-2) to ensure you are procuring the correct compound. Key factors to consider include:

• Purity: Aim for ADHP with high purity, typically 97% or above, for reliable experimental results or synthesis.
• Supplier Reputation: Choose established chemical suppliers known for their quality control and customer service. Manufacturers in China often provide competitive pricing and a wide range of chemical products.
• Technical Support: A good supplier will offer technical data sheets, safety information, and potentially application support.
• Pricing and Quantity: Obtain quotes for the required quantities, whether for laboratory research or larger-scale production. Suppliers will often offer different price tiers based on volume.

Many global chemical providers list ADHP for sale, with specialized manufacturers in China being significant sources. When you search for 'ADHP price' or 'purchase CAS 119171-73-2,' you will find numerous options. It is advisable to compare several suppliers to find the best combination of quality, price, and reliability.

Conclusion

10-Acetyl-3,7-dihydroxyphenoxazine (ADHP) is a versatile compound with significant applications in both biochemical research and pharmaceutical synthesis. Its ability to serve as a sensitive fluorogenic probe and a functional intermediate makes it an indispensable tool. By understanding its properties and carefully selecting a supplier, researchers and manufacturers can effectively integrate ADHP into their projects, driving innovation and discovery.