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Advancements in Camptothecin Derivatives for Oncology

Camptothecin and its derivatives represent a cornerstone in the development of anticancer drugs. These compounds are known for their ability to inhibit DNA Topoisomerase I, an enzyme critical for DNA replication and transcription. By trapping Topoisomerase I in a cleavable complex with DNA, they lead to DNA strand breaks and subsequent cell death, particularly in rapidly proliferating cancer cells. NINGBO INNO PHARMCHEM CO.,LTD. actively participates in this field by supplying high-quality pharmaceutical intermediates essential for the synthesis of these advanced therapeutics.

Belotecan Hydrochloride (CKD-602) stands out as a significant advancement within the camptothecin family. It is a semi-synthetic, water-soluble derivative that offers improved pharmacological properties compared to its predecessors. Research has highlighted its potent antitumor activity, demonstrating efficacy against a range of cancers, including gliomas, cervical cancer, and oral squamous cell carcinoma. The drug works by inducing G2/M phase arrest and promoting apoptosis in cancer cells, making it a valuable agent for targeted cancer therapy.

The ongoing quest for more effective and safer cancer treatments drives the continuous exploration of camptothecin analogues. NINGBO INNO PHARMCHEM CO.,LTD. plays a vital role in this process by providing reliable access to key intermediates like Belotecan Hydrochloride. For researchers and pharmaceutical manufacturers looking to buy Belotecan Hydrochloride, partnering with a trusted supplier like NINGBO INNO PHARMCHEM CO.,LTD. ensures the quality and consistency needed for successful drug development and clinical trials. This commitment to quality intermediates supports the advancement of oncology treatments worldwide.

Manufacturing Facilities

NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

Professional Export Experience

to Global Customers

WHY CHOSE US?

1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;

2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;

3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

FAQ

  • A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.

  • A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.

  • A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.

CONTACT US
Should you need to contact us; you may call during regular business hours, Monday through Friday, 8am – 6 pm.
NINGBO INNO PHARMCHEM CO.,LTD.
Address: No.163 Ruiqing Rd.,Ningbo 315000 China
Phone: 86-574-87319282
Fax: 86-574-27912196
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