Alfacalcidol, also widely recognized by its CAS number 41294-56-8, stands as a crucial and potent synthetic analog of vitamin D. It is a key metabolite of vitamin D3, specifically known as 1-hydroxycholecalciferol or Alpha D3. As a high-purity chemical intermediate, Alfacalcidol powder serves as a foundational raw material in the development and production of various pharmaceutical products and nutritional supplements aimed at addressing significant health challenges, primarily related to bone health and calcium metabolism.

This white, crystalline powder boasts a purity level typically exceeding 99%, ensuring its efficacy and suitability for demanding applications in medicinal and dietary contexts. With the molecular formula C27H44O2, Alfacalcidol operates as a non-selective activator of the vitamin D receptor (VDR). Unlike native vitamin D3, which requires two hydroxylation steps (one in the liver and another in the kidneys) to become its biologically active form, 1,25-dihydroxyvitamin D3 (calcitriol), Alfacalcidol only requires hydroxylation in the liver at the 25th position. This makes it particularly valuable in patients with impaired renal function, where the kidney's ability to perform the second hydroxylation is compromised. This unique metabolic pathway provides a significant therapeutic advantage in treating conditions associated with kidney disease.

The primary applications of Alfacalcidol are centered around its profound effects on calcium and phosphorus homeostasis and bone metabolism. It is extensively used in the treatment of several debilitating bone disorders. One major application is in the management of osteoporosis, a condition characterized by decreased bone density and increased fracture risk. Alfacalcidol helps to improve calcium absorption from the gut, facilitate the mineralization of bone, and modulate bone remodeling processes, contributing to increased bone strength and reduced fragility.

Another critical therapeutic area for Alfacalcidol is renal osteodystrophy, a complex bone disease that affects individuals with chronic kidney disease (CKD). As mentioned, the impaired kidney function in CKD patients leads to reduced production of active vitamin D. Alfacalcidol bypasses this limitation, effectively providing the active metabolite needed to regulate calcium and phosphorus levels, suppress elevated parathyroid hormone (a key factor in renal osteodystrophy), and improve bone abnormalities.

Furthermore, Alfacalcidol is indicated for the treatment of hypocalcemia, a condition characterized by abnormally low levels of calcium in the blood. By enhancing intestinal calcium absorption, it helps to restore serum calcium levels to a healthy range. This is particularly useful in conditions like hypoparathyroidism or pseudohypoparathyroidism, where the body struggles to maintain proper calcium balance.

Beyond its use in prescribed medications, Alfacalcidol is incorporated into various nutritional supplements designed to support bone health, particularly in populations at risk of vitamin D deficiency or compromised vitamin D metabolism, such as the elderly. These supplements contribute to maintaining adequate calcium and phosphorus levels, essential for preserving bone density and preventing bone loss over time. Its effectiveness across different age groups, including adults, the elderly, and in some specific cases children under medical supervision, underscores its versatility and importance.

Alfacalcidol also plays a role in medical research, serving as a tool to investigate the pleiotropic effects of vitamin D receptor activation beyond mineral metabolism, including potential roles in immune regulation and cellular differentiation. The quality and manufacturing standards for Alfacalcidol powder are paramount, given its use in sensitive applications. Adherence to stringent quality control measures and certifications such as GMP (Good Manufacturing Practice), ISO 9001, and compliance with pharmacopoeial standards like USP and BP are essential to ensure purity, potency, and safety.

The global demand for high-quality Alfacalcidol powder remains strong, driven by the increasing prevalence of bone disorders associated with aging populations and chronic diseases. Sourcing this vital ingredient requires working with reliable partners committed to quality and transparency. Finding a trustworthy Alfacalcidol powder manufacturer is the first step for pharmaceutical companies and supplement producers. The selection of an Alfacalcidol supplier is critical, focusing on consistent product quality, documentation, and supply chain reliability. Factors influencing Alfacalcidol price include purity levels, production volume, market demand, and the supplier's quality certifications and reputation.

For businesses looking to buy Alfacalcidol or wishing to purchase Alfacalcidol in bulk for manufacturing purposes, thorough due diligence is necessary to ensure the source meets all regulatory and quality requirements. A reputable supplier can provide the necessary technical support and quality assurance documentation, making the sourcing process smoother and more secure. Alfacalcidol stands as a testament to the power of targeted nutrient therapy, offering significant benefits for patients struggling with various bone and mineral metabolism disorders. Its continued use and research promise further advancements in improving bone health outcomes worldwide.