Custom Manufacturing, Project Outsourcing, your Trusted Partner from China
The metastatic cascade – the process by which cancer cells spread from the primary tumor to distant sites – is a significant cause of cancer mortality. Consequently, compounds that can inhibit invasion and metastasis are highly sought after in oncology research. Astragaloside IV (AS-IV), a potent bioactive compound derived from Astragalus membranaceus, has emerged as a promising agent due to its demonstrated ability to interfere with these critical processes. For R&D scientists and procurement managers, understanding AS-IV's role in this area is vital.
Research indicates that AS-IV works through several molecular pathways to suppress cancer cell invasion and metastasis. A key mechanism involves its impact on Epithelial-Mesenchymal Transition (EMT), a cellular process that enables cancer cells to gain migratory and invasive properties. AS-IV has been shown to inhibit EMT by modulating key signaling pathways such as AKT/GSK-3β/β-catenin and TGF-β1. By downregulating factors associated with EMT, AS-IV helps maintain the epithelial phenotype of cells, thereby reducing their ability to invade surrounding tissues and enter the bloodstream or lymphatic system.
Furthermore, AS-IV influences the activity of matrix metalloproteinases (MMPs), enzymes that degrade the extracellular matrix, facilitating cell migration. By inhibiting MMPs and other related proteins, AS-IV effectively creates a barrier to invasive growth. Studies also highlight AS-IV's impact on signaling pathways like MAPK/ERK and PI3K/AKT, which are critical for cell motility and invasion. By modulating these pathways, AS-IV can significantly impede the metastatic potential of cancer cells.
For organizations involved in cancer research and drug development, sourcing reliable and high-quality AS-IV is paramount to effectively studying these complex mechanisms. As a dedicated manufacturer and supplier based in China, we offer premium Astragaloside IV (CAS: 84687-43-4) that meets rigorous purity standards. This ensures that your experiments on invasion and metastasis inhibition are accurate and reproducible. We invite you to contact us for inquiries regarding product availability, pricing, and bulk procurement. Partnering with us provides a crucial link in your supply chain, empowering your research into effective anti-metastatic therapies.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
