Azosemide, identified by its Chemical Abstracts Service (CAS) Registry Number 27589-33-9, stands as a significant chemical compound with the molecular formula C12H11ClN6O2S2 and a molecular weight of 370.84. It is also recognized by the EINECS number 248-549-7. This compound is a key intermediate in various chemical synthesis pathways and holds particular relevance in the pharmaceutical sector. Typically, Azosemide presents itself in the form of solid color crystals, a characteristic appearance crucial for initial identification and quality assessment. Its unique chemical structure, featuring a chlorobenzene ring, a tetrazole moiety, a sulfonamide group, and a thiophene ring linked via an amine, dictates its physical and chemical behavior as well as its potential biological activities.

While primarily recognized as a chemical raw material or intermediate, Azosemide is widely known for its association with the class of drugs known as loop diuretics. These compounds play a vital role in medicine by acting on the loop of Henle in the kidneys, where they inhibit the Na-K-2Cl cotransporter. This inhibition significantly reduces the reabsorption of sodium, potassium, and chloride ions from the tubular fluid back into the bloodstream, subsequently leading to increased excretion of water, sodium, and other electrolytes. This mechanism makes loop diuretics effective in managing conditions characterized by fluid overload, such as edema associated with heart failure, liver cirrhosis, and kidney disease, as well as hypertension. The availability of high-purity Azosemide raw material is therefore essential for the production of pharmaceutical formulations used in these critical applications.

Understanding the detailed chemical properties of Azosemide is paramount for its handling, storage, quality control, and application in synthesis. Key physical characteristics include its melting point, reported to be between 218-221°C. This melting range serves as a critical indicator of the compound's purity and crystalline form. While a precise boiling point is challenging to determine for solid compounds that may decompose upon heating, an estimated boiling point around 221°C has been provided. The density is roughly estimated at 1.6843, and the refractive index at 1.6100. Furthermore, the predicted pKa value of 3.58±0.10 suggests its acidic properties, particularly related to the tetrazole proton and potentially the sulfonamide proton under specific conditions. These properties, especially melting point and spectroscopic data, are fundamental checkpoints to confirm the identity and purity of Azosemide.

The integrity and purity of Azosemide raw material are non-negotiable, especially when it is intended for pharmaceutical synthesis or related applications. Impurities can significantly affect the efficacy and safety of the final product. Therefore, sourcing Azosemide with a high purity specification, typically 99% minimum, is crucial. Achieving this level of purity requires sophisticated synthesis routes and rigorous purification processes. Analytical techniques such as High-Performance Liquid Chromatography (HPLC) are indispensable for quantifying the main compound and detecting potential impurities. Other methods like Karl Fischer titration for water content and spectroscopic analysis further ensure the quality meets stringent industry standards.

The manufacturing process for Azosemide involves complex chemical synthesis steps, starting from suitable precursors. Each stage of the synthesis must be carefully controlled to maximize yield and minimize impurity formation. Following synthesis, rigorous purification techniques are employed to achieve the desired high level of purity, typically specified at 99% minimum. Quality control is paramount throughout this process. Utilizing advanced analytical methods is key. Techniques such as High-Performance Liquid Chromatography (HPLC) are used to determine the exact purity percentage and identify any trace impurities. Mass Spectrometry (MS), Nuclear Magnetic Resonance (NMR) spectroscopy, and Infrared (IR) spectroscopy are employed to confirm the molecular structure and identity of the synthesized Azosemide. Additionally, tests for moisture content (e.g., Karl Fischer titration), heavy metals, and residual solvents are standard practice to ensure the raw material is safe and suitable for its intended use, especially in pharmaceutical applications.

Proper packaging and storage are essential to maintain the quality and stability of Azosemide. As a solid crystalline powder, it is typically packaged in containers that protect it from moisture, light, and contamination. Common packaging options might include sealed bags, drums, or other appropriate chemical containers, often nitrogen-purged to minimize degradation. Storage conditions, including temperature and humidity, must be controlled according to the supplier's recommendations to prevent physical changes or chemical decomposition. A reliable supplier like NINGBO INNO PHARMCHEM CO.,LTD. ensures that products are packaged and handled correctly to preserve their integrity from the point of manufacture to delivery.

NINGBO INNO PHARMCHEM CO.,LTD. serves as a dedicated and experienced supplier of high-quality chemical raw materials, including Azosemide CAS 27589-33-9. The company's expertise lies in sourcing and providing materials that adhere to stringent international quality standards, catering specifically to the demands of the pharmaceutical industry and other sectors requiring high-purity chemicals. Their rigorous internal quality control procedures complement the manufacturer's testing, providing an additional layer of assurance to their clients. By partnering with NINGBO INNO PHARMCHEM CO.,LTD., customers gain access to reliable products backed by technical support and a commitment to consistent supply.

For companies and researchers requiring Azosemide CAS 27589-33-9, identifying a dependable manufacturer and supplier is a critical step. NINGBO INNO PHARMCHEM CO.,LTD. is well-positioned to serve as your trusted partner for this essential raw material. We encourage potential clients to directly inquire about the competitive price for Azosemide and discuss their specific volume requirements, whether for R&D or large-scale production. Obtaining information on how to efficiently buy or purchase the product, including details on lead times, shipping logistics, and available payment terms, is straightforward. By choosing a reputable supplier, you ensure a smooth procurement process and secure access to the high-quality Azosemide needed for your critical applications.