Baclofen, a crucial pharmaceutical active ingredient, stands as a cornerstone in the treatment of various muscle movement disorders. Known chemically as (RS)-4-Amino-3-(4-chlorophenyl)butanoic acid, this white to off-white crystalline powder, with a CAS number of 1134-47-0 and molecular formula C10H12ClNO2, is widely recognized for its potent muscle relaxant properties. It primarily targets the central nervous system, offering significant relief from the debilitating effects of muscle spasticity.

As a highly purified compound, typically exceeding 99% purity, Baclofen adheres to stringent pharmaceutical standards such as USP and BP. Its slight solubility in water and very slight solubility in methanol, coupled with good solubility in dilute acids and bases, underscores its versatility in various formulations. The melting point, usually around 206-210°C, further confirms its consistent chemical integrity. Baclofen functions as a gamma-aminobutyric acid (GABA) derivative, specifically an agonist of GABAB receptors. This mechanism allows it to effectively inhibit the release of excitatory neurotransmitters in the spinal cord, leading to its characteristic antispasmodic effects.

The primary application of Baclofen is in managing spasticity, a condition characterized by muscle stiffness and involuntary spasms, commonly associated with medical challenges such as multiple sclerosis, spinal cord injuries, and cerebral palsy. By reducing muscle tightness and cramping, Baclofen significantly improves patient comfort and mobility, often enabling more effective physical therapy. It is also found to be beneficial in alleviating persistent hiccups and muscle spasms experienced in palliative care settings, providing much-needed relief.

Beyond its core indications, Baclofen has demonstrated utility in other therapeutic areas, including off-label applications. Research suggests its potential in treating alcohol use disorder, where it helps reduce relapse risk and extend periods of abstinence. It has also shown promise in managing opioid withdrawal symptoms and is incorporated by compounding pharmacies into topical pain creams, offering a localized muscle relaxant effect. A notable advantage of Baclofen is the low incidence of tolerance development, meaning its therapeutic benefits can be maintained over many years of continuous use, though patients receiving intrathecal administration should be monitored for this.

Baclofen can be administered through various routes, including oral tablets, solutions, or granules, offering flexibility in patient care. For severe, intractable spasticity, intrathecal administration via an implanted pump delivers the medication directly to the spinal fluid, providing highly effective relief with significantly lower systemic doses and fewer side effects. While generally well-tolerated, it is crucial to administer Baclofen under medical supervision. Common side effects are usually mild and include drowsiness or dizziness, which often subside as the body adjusts. Abrupt discontinuation of Baclofen, especially after prolonged use, must be avoided due to the risk of withdrawal syndrome, which can manifest as severe symptoms including hallucinations and seizures. Gradual tapering of the dose is essential for safe cessation. Patients with certain pre-existing conditions, such as kidney disease or epilepsy, should use Baclofen with caution, and its use during pregnancy should be carefully considered due to potential risks.

Ensuring the highest quality of pharmaceutical raw materials is paramount for patient safety and product efficacy. As a dedicated manufacturer and supplier of Baclofen API, we prioritize rigorous quality control at every stage of production, adhering strictly to international standards like GMP, ISO 9001, USP, and BP. We conduct comprehensive testing to guarantee the purity, stability, and efficacy of our Baclofen powder. For those looking to buy Baclofen or seeking a reliable Baclofen supplier, we offer competitive Baclofen price options, accommodating various purchase quantities from small pilot batches to large-scale industrial orders. Our commitment is to provide a consistent and dependable supply of this essential pharmaceutical intermediate, ensuring seamless operations for our global partners.