In the realm of advanced chemical synthesis, particularly for research and development in the life sciences, specific amino acid derivatives are indispensable. Boc-D-2-Cyanophenylalanine (CAS: 261380-28-3), often abbreviated as Boc-D-2-CN-phe, is one such compound that has gained significant traction. This article aims to provide a comprehensive overview of its properties and guide procurement professionals and researchers in sourcing this critical material.

Understanding the Chemical Profile of Boc-D-2-Cyanophenylalanine

Boc-D-2-Cyanophenylalanine is characterized by its D-configuration, the presence of a Boc (tert-butyloxycarbonyl) protecting group, and a cyano substituent at the ortho position of the phenyl ring. Its molecular formula is C15H18N2O4, with a molecular weight of approximately 290.32 g/mol. Typically appearing as a white to off-white solid or powder, it often has a melting point in the range of 82-91°C, as indicated by various chemical databases. The high purity, commonly exceeding 97% via HPLC, is crucial for its application in sensitive synthetic processes.

Key Applications in Scientific Research

The versatility of Boc-D-2-Cyanophenylalanine stems from its unique chemical structure, making it a valuable asset in several scientific disciplines:

• Peptide Synthesis: It serves as a crucial non-canonical amino acid for incorporating unique structural and functional motifs into peptides, which can lead to enhanced biological activity or stability.
• Medicinal Chemistry: Researchers utilize it as a building block for synthesizing novel small molecules with potential therapeutic applications. The cyano group can act as a bioisostere or a reactive handle for further chemical modifications.
• Bioconjugation and Drug Delivery: Its structure can be leveraged in designing specialized linkers or modifying biomolecules for targeted delivery systems.
• Neuroscience Research: It may be used in studies investigating specific neurological pathways or developing modulators for receptors.

Sourcing Strategies for Procurement Managers

For laboratories and pharmaceutical companies, sourcing Boc-D-2-Cyanophenylalanine requires careful consideration of supplier reliability, product quality, and cost-effectiveness. When looking to purchase this compound:

• Verify Purity and Specifications: Always request a Certificate of Analysis (CoA) that confirms the purity (e.g., ≥97% HPLC) and details other critical parameters.
• Identify Reputable Suppliers: Look for suppliers with a strong presence in the fine chemical market, especially those specializing in amino acids and peptide synthesis reagents. Many researchers prefer to buy from manufacturers in China due to competitive pricing and established supply chains.
• Request Quotes: Obtain quotes for the required quantities. Pricing can vary significantly, and bulk orders often come with discounts.
• Check Availability and Lead Times: Confirm that the product is in stock or understand the lead time for production and delivery to ensure your project timelines are met.

By paying close attention to these aspects, procurement professionals can ensure they acquire high-quality Boc-D-2-Cyanophenylalanine, thereby supporting the success of their research and development initiatives.