Calcium D-Pantothenate: A Vital Nutrient and Versatile Industrial Compound

Calcium D-Pantothenate, also widely known as Vitamin B5 or D-Pantothenic acid calcium salt (CAS No. 137-08-6), stands as a cornerstone in both biological systems and diverse industrial applications. This essential nutrient is a calcium salt of the D-isomer of pantothenic acid, playing an indispensable role in maintaining fundamental bodily functions and enhancing product efficacy across multiple sectors.

Chemically, Calcium D-Pantothenate typically appears as a white powder. Its molecular formula is C18H32CaN2O10, with a molecular weight of 476.53. Key physical properties include a melting point around 190 °C and high water solubility, at approximately 50 mg/mL at 25 °C. For optimal preservation of its quality and stability, it is recommended to store this compound in a well-closed, light-resistant, dry, and cool place, ideally at 2-8°C.

At the heart of its biological significance, Calcium D-Pantothenate serves as a crucial precursor for the biosynthesis of coenzyme A (CoA). CoA is a pivotal cofactor involved in an extensive array of metabolic pathways vital for life. It is instrumental in the Krebs cycle, the central energy-yielding process of cells, by facilitating the synthesis of acetyl-CoA, which acts as a bridge connecting carbohydrate, fat, and protein metabolism. Beyond energy production, CoA, and thus Vitamin B5, are essential for the synthesis and oxidation of fatty acids, as well as the decarboxylation of keto acids, underscoring its multifaceted and indispensable role in cellular biochemistry.

The applications of Calcium D-Pantothenate are remarkably broad and span across several key industries:

• Nutritional Supplements and Food Additives: As a nutritional supplement, it is a common ingredient in multivitamins and fortified foods. It supports energy metabolism, contributes to healthy skin, hair, and eyes, and ensures adequate vitamin intake, particularly in processed food products.


• Animal Feed: In the animal husbandry sector, Calcium D-Pantothenate is incorporated into animal feed formulations. It helps to enhance growth, improve feed efficiency, and contributes to the overall health and vitality of livestock, poultry, and aquaculture.


• Cosmetics and Personal Care: Due to its moisturizing and skin-conditioning properties, it is a popular ingredient in cosmetic formulations. It improves skin hydration, elasticity, and has anti-inflammatory effects, making it beneficial for various skincare products, including creams, lotions, and hair care items.


• Pharmaceuticals: In the pharmaceutical industry, its role as a precursor to coenzyme A is leveraged in various biochemical reactions crucial for drug formulation and development. It can support metabolic processes targeted by certain therapeutic agents.


• Research and Biotechnology: Calcium D-Pantothenate is widely used in microbiological culture media, facilitating the growth of various microorganisms. This makes it invaluable for studying microbial metabolism and genetics, as well as in the industrial production of antibiotics and other bioactive compounds through fermentation processes. Its contribution extends to elucidating enzyme mechanisms and investigating metabolic pathways in advanced research settings.

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