Carbenicillin Disodium, identified by CAS 4800-94-6, stands as a pivotal broad-spectrum penicillin antibiotic, recognized for its formidable efficacy against a wide array of bacterial pathogens. This compound functions by actively inhibiting the synthesis of bacterial cell walls, leading to cell lysis and ultimately, the demise of the microorganism. Its mechanism involves acylating the penicillin-sensitive transpeptidase C-terminal area by opening the lactam ring, thereby disrupting the crucial cross-linkage of peptidoglycan strands, a vital step in bacterial cell wall construction.

One of the primary applications of Carbenicillin Disodium is in the treatment of systemic infections caused by Pseudomonas aeruginosa, a notorious bacterium often associated with challenging hospital-acquired infections. Beyond this, it demonstrates significant antibacterial effects against a variety of Enterobacteriaceae, including Escherichia coli, Proteus, Enterobacter, Citrate, Salmonella, and Shigella. It also proves effective against other Gram-negative bacteria such as Haemophilus influenzae and Neisseria. Furthermore, this versatile antibiotic exhibits activity against certain Gram-positive bacteria like hemolytic streptococcus, streptococcus pneumoniae, and non-penicillinase-producing staphylococcus. Many anaerobic bacteria, including Bacteroides fragilis and Clostridium, are also sensitive to its action.

In laboratory and research settings, Carbenicillin Disodium offers distinct advantages over other common antibiotics like ampicillin. Crucially, it maintains its stability after being autoclaved, a critical feature for preparing sterile media and solutions without compromising its efficacy. This characteristic makes it an invaluable tool in genetic transformation applications, where it is frequently used to select for Ampicillin-resistant (AmpR) transformed cells. Its utility extends to plant biology, where it can regulate bacterial growth in plant cultures, exhibiting low toxicity to plant tissues, and serving as a gene selection antibiotic within advanced systems like CRISPR/CAS9.

Carbenicillin Disodium is typically presented as a white powder, assuring high purity standards essential for both pharmaceutical and research applications. Reputable manufacturers and suppliers ensure that this product meets stringent quality specifications, often boasting purity levels exceeding 99% and high assay values, confirmed through methods like HPLC. Proper storage in a cool and dry place, typically between 2°C and 8°C, is vital to preserve its potency and extend its shelf life, which commonly ranges up to two years. When considering where to buy or purchase this essential antibiotic, it is advisable to seek suppliers who can provide comprehensive Certificates of Analysis and demonstrate a commitment to quality control.

For those looking to procure high-quality Carbenicillin Disodium, whether for pharmaceutical formulation or advanced research, it is important to connect with an experienced supplier. Detailed product specifications, competitive price options, and reliable delivery are key considerations. Whether you are a large-scale manufacturer or a research institution, a trusted Carbenicillin Disodium supplier can meet your specific needs for this critical pharmaceutical intermediate.