Carbenoxolone Powder, identified by CAS number 5697-56-3, stands as a significant raw material in the pharmaceutical and cosmetic industries. Derived from the ubiquitous licorice plant (Glycyrrhiza glabra), this white crystalline powder is a semi-synthetic derivative of glycyrrhetinic acid, the main active component of licorice extract. Its unique chemical structure, C34H50O7, underpins its diverse biological activities and wide range of applications.

The journey of Carbenoxolone begins with glycyrrhizic acid, which is extracted from licorice root. In the human body, or through specific processing, glycyrrhizic acid is hydrolyzed to form glycyrrhetinic acid. Carbenoxolone is then synthesized from glycyrrhetinic acid, modifying the structure to enhance specific pharmacological properties while aiming to mitigate some potential side effects associated with the parent compound. This process yields a highly purified substance, typically reaching 99% purity or higher, crucial for its efficacy and safety in various end products.

Historically and pharmacologically, Carbenoxolone is best known for its potent anti-ulcer properties. It was one of the early successful treatments for gastric and duodenal ulcers. Its mechanism of action in treating ulcers is multifaceted. It is believed to protect the gastric mucosa by increasing mucus secretion and viscosity, thereby forming a protective barrier against stomach acid and pepsin. Additionally, it may prolong the lifespan of epithelial cells in the stomach lining and improve local blood flow, contributing to tissue repair and healing. Some studies also suggest it might inhibit certain enzymes, leading to localized increases in cortisol levels, which can exert anti-inflammatory effects on the ulcerated tissue without systemic corticosteroid side effects at therapeutic doses.

Beyond its gastrointestinal applications, Carbenoxolone demonstrates significant anti-inflammatory, anti-allergic, and antiviral activities. Its anti-inflammatory effects are comparable to some corticosteroids, although its mechanism of action is distinct. This makes it valuable in formulations aimed at reducing inflammation in various contexts. The antiviral properties have been explored, particularly against certain types of viruses, adding another dimension to its potential uses in healthcare products.

In the realm of cosmetics and personal care, Carbenoxolone Powder is gaining recognition for its benefits for the skin. Its properties make it a valuable ingredient in topical formulations. It exhibits antioxidant activity, helping to protect skin cells from damage caused by free radicals, which contributes to anti-aging effects. Its ability to inhibit melanin production can aid in skin brightening and reducing the appearance of dark spots. Furthermore, its antibacterial and anti-inflammatory qualities make it suitable for products targeting acne or sensitive, irritated skin, helping to regulate the skin's immune function and enhance its resistance to environmental stressors.

The quality of Carbenoxolone Powder is paramount for its performance in both pharmaceutical and cosmetic applications. High-purity material, verified through stringent testing methods such as High-Performance Liquid Chromatography (HPLC), ensures consistency and efficacy. Reputable manufacturers adhere to strict quality control standards throughout the production process, from the sourcing of licorice extract to the final powder form. This includes checks for heavy metals, microbial counts, and other impurities, ensuring the product meets international quality benchmarks like GMP and ISO standards, although specific certifications held by the manufacturer should always be verified by the purchaser.

Packaging and storage are also critical to maintain the integrity of Carbenoxolone Powder. It is typically supplied in sealed containers like bags (e.g., 1kg) or drums (e.g., 25kg), designed to protect it from moisture, light, and contamination. Proper storage in a cool, dry place, away from direct sunlight and heat, is essential to preserve its stability and ensure it retains its purity and activity throughout its shelf life, which is typically stated as two years under recommended conditions.

For companies operating in the pharmaceutical, nutraceutical, and cosmetic sectors, sourcing high-quality Carbenoxolone Powder is a key step in product development and manufacturing. The versatility of this raw material allows for its incorporation into a wide array of products, from oral medications for ulcers to topical creams for skin health. Its established efficacy and safety profile, when used appropriately and sourced from reliable origins, make it a valuable asset.

When seeking a dependable manufacturer or supplier of high-purity Carbenoxolone Powder (CAS 5697-56-3), it is crucial to perform thorough due diligence. Factors such as the manufacturer's quality assurance processes, production capacity, testing capabilities, and experience in handling pharmaceutical or cosmetic raw materials should be carefully evaluated. Inquiring about the current price, minimum order quantity (MOQ), packaging options, and lead times is a standard part of the procurement process. For businesses looking to buy Carbenoxolone Powder or purchase bulk quantities for their production needs, establishing a relationship with a trustworthy supplier like NINGBO INNO PHARMCHEM CO.,LTD. ensures a consistent supply of material that meets stringent quality specifications. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality chemical raw materials, supporting the development of innovative products across various industries.