For professionals in the chemical and pharmaceutical industries, understanding precise nomenclature and identification is crucial. The CAS Registry Number, a unique numerical identifier, plays a vital role in distinguishing chemical substances. Today, we focus on CAS 143824-78-6, which identifies the important peptide synthesis reagent, Fmoc-Trp(Boc)-OH, also known as N-alpha-Fmoc-N-in-Boc-L-tryptophan. This article aims to clarify its significance and guide you on where to buy this essential compound.

Fmoc-Trp(Boc)-OH is a specially protected derivative of the amino acid tryptophan. The Fmoc (9-fluorenylmethyloxycarbonyl) group protects the alpha-amino group, a standard practice in Fmoc-based Solid-Phase Peptide Synthesis (SPPS). More critically, the 'Boc' (tert-butyloxycarbonyl) group is attached to the indole nitrogen of the tryptophan side chain. This N-in-Boc protection is key to its utility. It serves to prevent electrophilic attack on the indole ring during the harsh deprotection and cleavage steps, thereby avoiding side reactions that could compromise the purity and yield of synthesized peptides. When researchers need to buy Fmoc-Trp(Boc)-OH, they are looking for this specific protection strategy to ensure successful synthesis of tryptophan-containing peptides.

The importance of CAS 143824-78-6 is evident in its widespread use in research and development, particularly in the synthesis of complex peptides for therapeutic applications. For instance, when synthesizing peptides that also contain arginine, which can lead to issues with side-chain deprotection, the N-in-Boc protection of tryptophan in Fmoc-Trp(Boc)-OH helps mitigate these problems. This results in cleaner peptide products and higher overall yields, making it a valuable component for any peptide chemist. Manufacturers and suppliers often list this CAS number prominently when offering the product, allowing easy identification for bulk orders and inquiries.

Finding a reliable supplier for chemicals identified by their CAS number is essential. When you search to buy Fmoc-Trp(Boc)-OH, looking for suppliers that clearly state CAS 143824-78-6 alongside detailed specifications and purity information is a good practice. Many leading chemical manufacturers and distributors, particularly those specializing in amino acids and peptide synthesis reagents, offer this compound. Sourcing from a reputable manufacturer in China can provide cost efficiencies without sacrificing the quality necessary for rigorous research and pharmaceutical development.

In essence, understanding the CAS number 143824-78-6 for Fmoc-Trp(Boc)-OH is fundamental for chemists and procurement specialists. It ensures you are acquiring the correct, appropriately protected derivative for successful peptide synthesis, aiding in the development of critical pharmaceutical products.