In the intricate landscape of chemical compounds, each CAS (Chemical Abstracts Service) number represents a unique molecular identity, serving as a universal identifier for researchers, manufacturers, and regulatory bodies. CAS 2022-78-8, specifically denoting 5-Fluoro-2-hydroxypyrimidine, is a compound of significant interest, particularly within the pharmaceutical and organic synthesis sectors. This article aims to demystify its properties, applications, and the best practices for its procurement.

What is CAS 2022-78-8?

CAS 2022-78-8 identifies 5-Fluoro-2-hydroxypyrimidine. This compound, with the molecular formula C4H3FN2O and a molecular weight of 114.08 g/mol, is a derivative of pyrimidine, featuring a fluorine atom at the 5th position and a hydroxyl group (or its tautomeric keto form) at the 2nd position. It typically presents as a white to off-white powder, a physical characteristic that is important for its handling and application in various chemical processes. The melting point of this compound is generally reported in the range of 170-174 °C.

Key Applications and Uses

The structural features of 5-Fluoro-2-hydroxypyrimidine make it a valuable intermediate in several critical fields:

• Pharmaceutical Intermediates: This is arguably its most significant application. The presence of fluorine can profoundly influence the biological activity and pharmacokinetic properties of drug molecules. It is used as a building block in the synthesis of various APIs, contributing to the development of new therapeutic agents. Researchers aiming to buy 5-Fluoro-2-hydroxypyrimidine often do so for its potential to enhance drug efficacy and stability.
• Organic Synthesis: As a versatile reagent, it participates in numerous organic reactions, allowing for the introduction of the fluoropyrimidine moiety into larger, more complex organic structures. This is essential for chemists engaged in novel compound discovery and custom synthesis projects.
• Chemical Research: In academic and industrial research laboratories, CAS 2022-78-8 serves as a tool for exploring new reaction pathways, synthesizing novel materials, and investigating structure-activity relationships.

Procurement Best Practices for CAS 2022-78-8

When you need to purchase CAS 2022-78-8, selecting the right supplier is paramount. Here are some tips to ensure a successful procurement:

• Verify Purity and Specifications: Always confirm the purity level, typically 98% or higher, and ensure the physical form (powder) meets your needs. Request a Certificate of Analysis (CoA) for each batch.
• Source from Reputable Manufacturers: Prioritize suppliers who are direct manufacturers, particularly those based in regions with strong chemical production capabilities like China. This often leads to better pricing and supply chain reliability.
• Inquire About Pricing and Minimum Order Quantities: For bulk requirements, directly asking for a quote from a supplier for 5-Fluoro-2-hydroxypyrimidine can reveal significant cost savings. Understand their minimum order quantity (MOQ) policies.
• Check Safety Information: Ensure that comprehensive safety data, including hazard codes (e.g., Xi) and safety statements, are readily available for safe handling and compliance.
• Evaluate Logistics and Delivery: Understand the shipping options, Incoterms, and estimated delivery times to ensure timely receipt of your order.

In conclusion, CAS 2022-78-8, or 5-Fluoro-2-hydroxypyrimidine, is an indispensable compound for many advanced chemical applications. By approaching its procurement with diligence and choosing reliable suppliers, you can effectively integrate this valuable intermediate into your research and production workflows.