In the intricate world of pharmaceutical synthesis, specific chemical compounds serve as indispensable building blocks for creating life-saving drugs. One such compound, identified by its CAS number 221640-06-8, is (2S)-N1-(2-aminoethyl)-3-(4-ethoxyphenyl)propane-1,2-diamine trihydrochloride. This molecule, a trihydrochloride salt of a diamine derivative, plays a pivotal role in the production of various pharmaceutical agents, most notably as a key intermediate in the synthesis of Sofosbuvir. For R&D scientists and procurement professionals in the pharmaceutical industry, understanding this compound, its suppliers, and its applications is crucial for efficient and cost-effective drug development.

Understanding CAS 221640-06-8: Properties and Significance

The chemical name (2S)-N1-(2-aminoethyl)-3-(4-ethoxyphenyl)propane-1,2-diamine trihydrochloride precisely describes its structure: a chiral diamine with an ethoxyphenyl group, presented as a trihydrochloride salt. This form enhances its stability and handling characteristics. Typically, this compound presents as a white powder, a critical physical property for quality assessment. Its molecular formula is C13H26Cl3N3O, with a molecular weight of approximately 346.72400. The purity level is a paramount specification for its use in pharmaceutical manufacturing, with standards often requiring 98.0% or higher. Its primary application lies in its role as a vital intermediate for APIs, underscoring the importance of reliable manufacturers who can consistently supply this high-purity material.

Finding Reliable Manufacturers and Suppliers

For any pharmaceutical company looking to source CAS 221640-06-8, identifying trustworthy manufacturers and suppliers is the first step towards a successful procurement process. The global market offers various sources, with China being a significant hub for chemical manufacturing. When seeking a supplier, consider these factors:

• Product Purity: Always verify the purity specifications. Manufacturers should provide a Certificate of Analysis (CoA) detailing the purity and other critical parameters.
• Production Capacity: Ensure the supplier can meet your volume requirements, whether for research quantities or large-scale industrial production.
• Consistency: Reliable suppliers demonstrate batch-to-batch consistency, which is essential for reproducible drug manufacturing processes.
• Regulatory Compliance: While intermediates may not always require GMP certification themselves, working with suppliers who understand and adhere to stringent quality control practices is beneficial.
• Competitive Pricing: Obtain quotes from multiple suppliers to ensure you are receiving a competitive price for this important intermediate. Understanding the price per kilogram or gram is key for budgeting.

The Role of this Diamine in Drug Synthesis

The utility of (2S)-N1-(2-aminoethyl)-3-(4-ethoxyphenyl)propane-1,2-diamine trihydrochloride extends beyond its immediate chemical structure. Its chiral nature and the presence of multiple amine functional groups make it an ideal precursor for complex molecular architectures. Its established role as an intermediate for Sofosbuvir is a testament to its synthetic utility. For companies involved in generic drug manufacturing or the development of new antiviral therapies, securing a consistent supply of this compound is a strategic advantage.

How to Purchase CAS 221640-06-8

Purchasing CAS 221640-06-8 involves engaging with chemical suppliers. Prospective buyers can initiate contact by submitting an inquiry detailing their required quantity, purity specifications, and any specific packaging needs. Requesting a formal quotation will provide pricing and delivery timelines. Many suppliers also offer smaller quantities for laboratory research and development purposes, allowing scientists to evaluate the compound before committing to larger orders. When you decide to buy, ensure you are working with a supplier that prioritizes quality assurance and has a transparent pricing structure.

In summary, CAS 221640-06-8, (2S)-N1-(2-aminoethyl)-3-(4-ethoxyphenyl)propane-1,2-diamine trihydrochloride, is a valuable pharmaceutical intermediate. By understanding its properties and diligently selecting a reliable manufacturer and supplier, pharmaceutical companies can ensure the continuity and quality of their drug production processes.