Carbonyldiimidazole (CDI), identified by its CAS number 530-62-1, is a highly effective and versatile reagent widely employed in organic synthesis, particularly for the formation of amide and ester linkages. Its ability to activate carboxylic acids efficiently makes it a preferred choice for chemists seeking to create these crucial functional groups in a controlled and mild manner.

The reaction of CDI with carboxylic acids generates a highly reactive acyl imidazole intermediate. This intermediate then readily reacts with amines to form amides, or with alcohols to form esters. These reactions are fundamental in the synthesis of a vast array of organic compounds, including pharmaceuticals, peptides, polymers, and fine chemicals. The mild reaction conditions typically associated with CDI's use are a significant advantage, as they help to preserve the integrity of sensitive substrates and minimize side reactions, which can often occur with more aggressive coupling agents.

The efficiency of CDI in forming amides is particularly noteworthy. It facilitates the amidation of unprotected alpha-amino acids under ambient, neutral conditions, making it an excellent reagent for peptide synthesis. Similarly, its esterification capabilities are broad, although alcoholysis may sometimes require heating or the presence of strong nucleophiles for optimal yields, especially with tertiary alcohols. The byproduct of these reactions is typically carbon dioxide and imidazole, which are generally benign and easily removed, simplifying purification processes.

NINGBO INNO PHARMCHEM CO.,LTD. is a reliable supplier of high-quality Carbonyldiimidazole, essential for various synthesis needs. Our commitment to purity and consistency ensures that our CDI can be effectively utilized for diverse applications, from laboratory research to industrial production. When you need to purchase CDI for the efficient synthesis of amides or esters, our product offers a reliable solution.

The broad utility of Carbonyldiimidazole in creating vital functional groups underscores its importance in modern synthetic chemistry. Its ease of handling and predictable reactivity make it an indispensable tool for chemists aiming for precision and efficiency in their synthetic endeavors.