Custom Manufacturing, Project Outsourcing, your Trusted Partner from China
Cefepime Hydrochloride is a synthetic, broad-spectrum, semi-synthetic antibiotic belonging to the cephalosporin class. Its chemical structure, characterized by a beta-lactam ring fused to a dihydrothiazine ring, is fundamental to its antibacterial activity. The fourth-generation status of Cefepime Hydrochloride signifies its enhanced potency and expanded spectrum of activity compared to earlier generations, particularly against Gram-negative bacteria and those with resistance mechanisms like beta-lactamase production.
At the pharmacological level, Cefepime Hydrochloride functions as a bacterial cell wall synthesis inhibitor. It achieves this by irreversibly binding to specific penicillin-binding proteins (PBPs), which are essential transpeptidases involved in the cross-linking of peptidoglycan. This disruption of peptidoglycan synthesis weakens the bacterial cell wall, leading to cell lysis and death. Its affinity for different PBPs can vary between bacterial species, contributing to its broad spectrum of action.
The pharmacokinetic properties of Cefepime Hydrochloride are crucial for its therapeutic efficacy. Following parenteral administration, it is rapidly absorbed into the bloodstream. Its distribution is wide, reaching various body tissues and fluids. The primary route of elimination for Cefepime Hydrochloride is renal excretion, with approximately 85% of an administered dose being recovered unchanged in the urine. This high degree of renal clearance means that patients with impaired kidney function require careful dose titration to avoid toxicity.
Metabolism of Cefepime Hydrochloride is limited. A small fraction undergoes metabolism to inactive compounds, primarily N-methylpyrrolidine (NMP), which is then further converted to NMP-N-oxide. Less than 1% of the dose is excreted as NMP and about 6.8% as NMP-N-oxide. The epimer of cefepime is also a minor metabolite. These metabolic pathways are not significant enough to alter the overall dosing strategy but are important for a complete understanding of the drug's disposition.
For the pharmaceutical industry, sourcing high-quality Cefepime Hydrochloride API is paramount. NINGBO INNO PHARMCHEM CO.,LTD. provides GMP-certified Cefepime Hydrochloride, ensuring that the chemical and pharmacological integrity of the API is maintained. This commitment to quality allows pharmaceutical manufacturers to develop consistent and effective Cefepime Hydrochloride formulations that meet the demanding requirements for treating severe bacterial infections. Understanding the intricate chemistry and pharmacology of Cefepime Hydrochloride empowers researchers and clinicians to utilize this vital antibiotic optimally.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
