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For chemists and researchers working in the pharmaceutical industry, a thorough understanding of the chemical and physical properties of intermediates is fundamental to successful synthesis. 4,6-Dichloro-2-methylpyrimidine (CAS 1780-26-3) is a heterocyclic organic compound belonging to the pyrimidine family, characterized by its specific arrangement of chlorine atoms and a methyl group on the pyrimidine ring.
Its molecular formula is C5H4Cl2N2, with a molecular weight of approximately 163.00 g/mol. As per typical supplier specifications, its appearance is an off-white crystalline powder. This crystalline nature is crucial for ease of handling and purification in chemical processes. While specific melting point data can vary slightly between manufacturers, it generally falls within a range suitable for many industrial synthesis applications.
Key chemical specifications often provided by manufacturers include an assay or purity level, typically ≥99.0% or ≥99.5%. This high purity is critical when the compound is used as an intermediate for Active Pharmaceutical Ingredients (APIs), where even trace impurities can affect the final drug product's efficacy, safety, and regulatory compliance. Parameters such as Loss on Dry (moisture content), typically <0.5%, and Residue on Ignition (inorganic content), usually <0.2%, are also important indicators of quality. These values ensure that the compound is stable and free from significant contaminants.
The reactivity of 4,6-Dichloro-2-methylpyrimidine, attributed to the labile chlorine atoms on the pyrimidine ring, makes it an excellent nucleophilic substitution substrate. This reactivity is precisely what makes it so valuable in organic synthesis, allowing for the facile introduction of various functional groups required for building more complex molecular structures. Its utility in constructing molecules like Dasatinib and Moxonidine stems directly from these chemical properties.
As a reliable chemical supplier, we emphasize the importance of these chemical and physical properties. Our manufacturing processes are designed to consistently yield 4,6-Dichloro-2-methylpyrimidine that meets the highest purity standards. For procurement managers and R&D scientists looking to buy this intermediate, understanding these specifications ensures they are sourcing a product that will perform optimally in their synthetic routes. We provide comprehensive technical data to support your project needs.
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