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In the intricate world of pharmaceutical synthesis, understanding the precise chemical properties of intermediates is paramount. 4-[(4-Chloro-2-pyrimidinyl)amino]-benzonitrile, known for its CAS number 244768-32-9, is a prime example of such a critical compound. As a key precursor in the synthesis of Rilpivirine, an essential drug in HIV treatment, its characteristics are a subject of keen interest for chemists and manufacturers alike. NINGBO INNO PHARMCHEM CO.,LTD. highlights the significance of these chemical details.
The compound presents as a white to yellow powder, a common physical form for many fine chemical intermediates. Its molecular formula, C11H7ClN4, and a molecular weight of 230.653 g/mol provide the basic structural information crucial for reaction planning. Beyond these fundamental identifiers, its physical and chemical properties offer deeper insights into its handling and application. The density of approximately 1.4±0.1 g/cm³ and a boiling point of 441.0±51.0 °C at 760 mmHg indicate its stability, even under relatively high temperatures and pressures encountered during synthesis. The flash point of 220.5±30.4 °C also provides important safety information for its manipulation.
One of the most compelling aspects of this compound is its assay, which typically meets or exceeds 99.0% as determined by High-Performance Liquid Chromatography (HPLC). This high level of purity, coupled with strict limits on single impurities (≤0.5%), moisture (≤0.5%), and sulfated ashes (≤0.3%), makes it an ideal candidate for pharmaceutical applications where precision is non-negotiable. Exploring the 4-chloro-2-pyrimidinylamino-benzonitrile properties reveals its suitability for complex organic synthesis.
The primary application of 4-[(4-Chloro-2-pyrimidinyl)amino]-benzonitrile is undeniably its role as a building block for Rilpivirine. This connection solidifies its importance within the pharmaceutical supply chain, directly contributing to the availability of critical antiretroviral therapies. Understanding these 4-chloro-2-pyrimidinylamino-benzonitrile uses is key for researchers and manufacturers seeking reliable pharmaceutical intermediates. NINGBO INNO PHARMCHEM CO.,LTD. remains dedicated to providing materials that meet these stringent requirements, supporting the advancement of global health.
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