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Understanding the precise chemical characteristics of intermediates is fundamental for efficient and successful synthesis in the pharmaceutical industry. 5-Hydroxyazaindole, identified by CAS number 98549-88-3, is a heterocyclic organic compound that plays a crucial role as a building block in complex chemical syntheses. This article explores its chemical profile, detailing its structure, properties, and common applications, providing valuable insights for researchers and manufacturers.
Chemically, 5-Hydroxyazaindole is characterized by its molecular formula C7H6N2O and a molecular weight of approximately 134.14 g/mol. Its structure features a pyrrolo[2,3-b]pyridine core, with a hydroxyl group (-OH) attached at the 5-position. This aromatic heterocyclic system imparts specific reactivity and stability, making it suitable for a variety of organic transformations. Typically appearing as a light yellow solid, 5-Hydroxyazaindole possesses a melting point in the range of 219-220°C, indicating its robust solid state under standard conditions.
The utility of 5-Hydroxyazaindole is primarily recognized in its role as a key intermediate in the synthesis of potent pharmaceutical agents. Most notably, it is a precursor for Venetoclax, a highly selective inhibitor of BCL-2 proteins, which is a significant advancement in oncology treatment. Its specific arrangement of nitrogen atoms and the hydroxyl group allows for targeted functionalization and coupling reactions, essential steps in building the complex molecular architecture of drugs like Venetoclax. Researchers often utilize this compound in scientific research laboratories for exploring new synthetic routes and developing novel medicinal chemistry entities.
As a supplier of high-quality chemical intermediates, we ensure that our 5-Hydroxyazaindole meets rigorous standards for research and manufacturing. The compound's predicted boiling point of approximately 381.8°C and a density of around 1.41 g/cm³ provide further physical parameters useful for process design. Its pKa value of approximately 6.93 suggests its behavior in different pH environments, which can be important for reaction optimization. For manufacturers and R&D professionals, understanding these chemical properties is vital for selecting the right synthesis strategies and ensuring the desired outcomes. We are committed to providing detailed technical specifications and consistent product quality to support your projects.
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