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Understanding the precise chemical profile of intermediates is fundamental for successful drug synthesis. Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate, identified by CAS number 27143-07-3, is a compound of significant interest in the pharmaceutical industry, primarily due to its role in the synthesis of apixaban. NINGBO INNO PHARMCHEM CO.,LTD. provides detailed information on this essential chemical intermediate, ensuring clarity for our partners.
The molecular formula of Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate is C11H13ClN2O3, with a corresponding molecular weight of 256.69 g/mol. This compound typically presents as a solid, often characterized by its light yellow to dark yellow color. Its melting point is reported around 94°C, and a boiling point of approximately 349°C at 760 mmHg. The compound's structure features an ester group, a chloro substituent, and a hydrazono linkage connected to a methoxyphenyl group, providing specific reactivity crucial for its subsequent transformations in synthetic pathways. The demand for high purity chemical intermediates like this is driven by the need for precise molecular construction in apixaban precursor manufacturing.
The synthesis of Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate generally involves a multi-step process. A common route begins with p-anisidine, which is diazotized and then coupled with ethyl 2-chloroacetoacetate under controlled conditions. This process requires careful management of temperature, pH, and reagent addition to maximize yield and minimize the formation of impurities. The efficiency and purity achieved in this chemical intermediate manufacturing directly impact the downstream production of apixaban. As a leading pharmaceutical intermediate supplier China, NINGBO INNO PHARMCHEM CO.,LTD. focuses on optimizing these synthetic routes.
The physical and chemical properties of Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate make it a versatile intermediate. Its solubility characteristics, for instance, in solvents like chloroform and methanol, are important considerations during process development and purification. For pharmaceutical companies looking to buy this intermediate, understanding these properties helps in integrating it seamlessly into their own manufacturing processes. The reliability of a supplier to consistently deliver material with these exact specifications is paramount.
In conclusion, the detailed chemical profile of Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate, from its molecular structure and physical properties to its synthesis, highlights its critical importance in the pharmaceutical supply chain. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing this essential intermediate with the highest standards of quality, supporting the production of vital medications globally.
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