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The Chemical Profile of (R)-Glycidyl Nosylate: A Synthesis Expert's View

For research scientists and product formulation chemists, a thorough understanding of chemical properties is fundamental to innovation. (R)-Glycidyl Nosylate (CAS 115314-17-5) is a compound that merits detailed examination due to its sophisticated structure and versatile reactivity, making it a prime candidate for advanced organic synthesis. This article aims to provide an in-depth look at its chemical profile, from synthesis and structure to its specific applications, from the perspective of an expert manufacturer.

The molecular identity of (R)-Glycidyl Nosylate is defined by its formula C9H9NO6S and a molecular weight of 259.24 g/mol. It presents as a white crystalline powder, a physical state indicative of its ordered molecular structure and purity. The melting point, typically between 59-63°C, is a critical parameter for quality control and characterization. The presence of both a chiral epoxide ring and a 3-nitrobenzenesulfonate (nosylate) group confers unique reactivity. The epoxide ring, being strained, is highly susceptible to nucleophilic attack, leading to ring-opening reactions. The electron-withdrawing nature of the nosylate group further enhances the electrophilicity of the epoxide, facilitating these reactions. This makes (R)-Glycidyl Nosylate a powerful tool for constructing complex chiral molecules with defined stereochemistry.

Synthesis of (R)-Glycidyl Nosylate typically involves reacting (R)-glycidol with 4-nitrobenzenesulfonyl chloride. The process requires careful control of reaction conditions to maintain the stereochemical integrity of the (R)-enantiomer. For researchers looking to buy (R)-Glycidyl Nosylate, understanding the synthesis route ensures the quality and reliability of the procured material. As a leading manufacturer, we employ advanced synthetic methodologies and rigorous purification techniques to achieve high enantiomeric purity, essential for its applications as a pharmaceutical intermediate and in other fine chemical syntheses.

The applications of this compound are vast, driven by its ability to act as a chiral synthon. In pharmaceutical research, it is instrumental in the synthesis of enantiomerically pure drugs. The precise stereochemistry enabled by (R)-Glycidyl Nosylate is critical for drug efficacy and safety, as different enantiomers can have vastly different biological activities. Beyond pharmaceuticals, its utility extends to the development of agrochemicals and specialty materials where precise molecular architecture is required. For scientists seeking to purchase (R)-Glycidyl Nosylate, understanding these applications highlights its strategic importance in driving innovation. The availability of high-purity material from a trusted supplier like us ensures that your research can proceed with confidence.

When considering the price and availability, it's important to note that the complexity of chiral synthesis impacts production costs. However, as a dedicated producer, we strive to offer competitive pricing for (R)-Glycidyl Nosylate, making this crucial building block accessible for R&D and larger-scale production. If you are interested in exploring the potential of this compound for your specific research or product development, we encourage you to inquire about our product specifications, lead times, and bulk purchase options. We are committed to supporting scientific advancement through the provision of high-quality chemical reagents.

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