For professionals in the chemical and pharmaceutical industries, a thorough understanding of a compound's properties is fundamental to its successful application. 2-Butyl-4-chloro-5-formylimidazole (CAS 83857-96-9) is a significant intermediate, particularly in the synthesis of antihypertensive drugs. This article provides a detailed overview of its key chemical and physical characteristics, essential knowledge for anyone looking to buy or utilize this compound.

Chemical Identity and Structure

2-Butyl-4-chloro-5-formylimidazole, with the CAS number 83857-96-9, possesses the molecular formula C8H11ClN2O and a molecular weight of 186.64 g/mol. Its structure features an imidazole ring, a five-membered heterocyclic aromatic ring containing two nitrogen atoms. This core is substituted with a butyl group at the 2-position, a chlorine atom at the 4-position, and a formyl (aldehyde) group at the 5-position. This specific arrangement of functional groups dictates its reactivity and utility in organic synthesis.

Physical Characteristics

The typical appearance of 2-Butyl-4-chloro-5-formylimidazole is that of a pale yellow to light yellow crystalline powder. Its melting point is reported to be in the range of 96-103°C, indicating it is a solid at room temperature. Solubility tests show it is slightly soluble in water but soluble in organic solvents such as methanol, ethanol, DMF, and DMSO. These solubility characteristics are important for reaction setup and purification processes.

Reactivity and Stability

The presence of the aldehyde group makes 2-Butyl-4-chloro-5-formylimidazole susceptible to oxidation and reduction reactions. The chlorine atom on the imidazole ring can also participate in nucleophilic substitution reactions under appropriate conditions. The compound is generally stable when stored under recommended conditions, typically in a cool, dry place, protected from light and moisture. For optimal long-term storage, especially for research-grade materials, refrigeration in an inert atmosphere is often advised, as indicated by some suppliers. Understanding its stability profile is key for ensuring its efficacy when used as a pharmaceutical intermediate.

Applications and Industry Relevance

The primary application of 2-Butyl-4-chloro-5-formylimidazole is as a key intermediate in the synthesis of Losartan, a widely used angiotensin II receptor blocker (ARB). Its specific structure is essential for constructing the Losartan molecule, which is critical for treating hypertension and other cardiovascular conditions. Beyond Losartan, this compound also finds use as a reference standard, such as Losartan EP Impurity D, for quality control in pharmaceutical manufacturing. Its versatility also hints at potential uses in agrochemical development and other areas of organic synthesis.

Procuring High-Quality 2-Butyl-4-chloro-5-formylimidazole

For procurement managers and researchers, securing a reliable source for 2-Butyl-4-chloro-5-formylimidazole is paramount. Manufacturers like NINGBO INNO PHARMCHEM CO., LTD. provide this intermediate with guaranteed purity and detailed technical specifications. Our commitment to quality ensures that your production processes are supported by dependable materials. Contact us to learn more about purchasing this crucial chemical intermediate and to receive a competitive quote.

A deep understanding of chemical properties empowers efficient utilization. We aim to be your trusted source for high-quality chemical intermediates like 2-Butyl-4-chloro-5-formylimidazole.