For chemists, formulators, and procurement specialists, a deep understanding of a chemical’s properties is fundamental to its successful application and safe handling. 5,6,7,8-Tetrahydro-2-naphthol (CAS 1125-78-6) is a compound of significant interest due to its utility as an intermediate in advanced synthesis, particularly in the OLED materials and pharmaceutical sectors. This article provides a focused look at its key chemical characteristics and handling requirements.

Chemical Identity and Structure

Product Name: 5,6,7,8-Tetrahydro-2-naphthol
CAS Number: 1125-78-6
Chemical Formula: C10H12O
Molecular Weight: 148.22 g/mol
Synonyms: 6-Tetralinol, 5,6,7,8-Tetrahydro-2-hydroxynaphthalene, 5,6,7,8-Tetrahydronaphthalen-2-ol.

The structure features a fused ring system: an aromatic benzene ring fused to a saturated cyclohexane ring, with a hydroxyl group attached to the aromatic ring at the 2-position (or 6-position relative to the saturated ring). This combination of aromaticity and aliphatic character, along with the reactive hydroxyl group, dictates its chemical behavior.

Key Physical and Chemical Properties

• Appearance: Typically described as a beige crystalline mass or solid.
• Melting Point: Around 57-61 °C. This relatively low melting point indicates it can be handled as a solid at room temperature but may melt easily.
• Boiling Point: Approximately 275-276 °C at 760 mmHg. This high boiling point suggests low volatility under standard conditions.
• Density: Around 1.0552 g/cm³.
• Solubility: Information on water solubility can vary, but it is generally considered to have limited solubility in water, common for compounds with substantial hydrocarbon character. It is likely soluble in organic solvents like ethanol or DMSO.
• Flash Point: Greater than 230 °F (>110 °C). This indicates it is not highly flammable, but standard precautions should still be taken.
• Reactivity: The phenolic hydroxyl group is the primary site of reactivity, allowing for reactions like O-alkylation, O-acylation, and other derivatizations. The aromatic ring can undergo electrophilic substitution, though the activating/deactivating effects of the hydroxyl and the saturated ring need consideration.

Safety and Handling Precautions

According to safety data, 5,6,7,8-Tetrahydro-2-naphthol can cause skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Therefore, proper handling is essential:

• Personal Protective Equipment (PPE): Wear appropriate gloves (e.g., nitrile), safety goggles with side-shields, and protective clothing to prevent skin and eye contact.
• Ventilation: Handle in a well-ventilated area or use local exhaust ventilation to minimize inhalation of dust or vapors.
• Storage: Store in a tightly closed container in a dry, cool, and well-ventilated place, away from incompatible materials.

Procurement and Application Context

When you are looking to buy 5,6,7,8-Tetrahydro-2-naphthol for your research or manufacturing, understanding these properties helps in selecting the right grades and planning your synthetic routes. As a manufacturer and supplier, providing accurate chemical property data is key to ensuring customers can utilize the compound effectively and safely. For specific inquiries regarding price or bulk purchase, engaging with a knowledgeable chemical supplier is recommended.