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For scientists and procurement professionals in the chemical and pharmaceutical industries, a deep understanding of a compound's chemical properties is fundamental to its effective application. 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one (CAS 120014-30-4) is one such compound, recognized for its significance as a pharmaceutical intermediate and an impurity standard in the synthesis of Donepezil.
Chemically, 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one possesses a molecular formula of C17H23NO3 and a molecular weight of approximately 289.37 g/mol. Its structure features an indanone core with dimethoxy substitutions and a piperidinyl-methylene group. This specific arrangement of functional groups makes it a suitable precursor in complex organic synthesis pathways, particularly for building the intricate structure of Donepezil, an acetylcholinesterase inhibitor used in Alzheimer's treatment.
The physical state of 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one is typically described as a solid. Its melting point is often cited around 258-260°C (with decomposition), which is a key characteristic for identification and quality assessment. Solubility data indicates it may have varying solubility in common organic solvents, which is an important consideration for its use in reaction media or analytical procedures. While specific detailed solubility information can vary by supplier and preparation, understanding its general behavior in solvents like DMSO or methanol is crucial for laboratory use.
As a pharmaceutical intermediate, the purity of 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one is paramount. Impurities present in the starting materials can lead to unwanted side reactions, reduced yields, and contamination of the final API. Therefore, manufacturers focus on synthetic routes that yield a high-purity product, often exceeding 95% or even 98% purity, as confirmed by analytical techniques like HPLC. The compound's role as a Donepezil impurity further underscores the need for accurate characterization and a well-defined impurity profile when it is used as a reference standard.
For researchers and procurement specialists looking to buy 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one, understanding these chemical properties is key to selecting the right product and supplier. Manufacturers who provide comprehensive technical data and reliable analytical support are invaluable partners in pharmaceutical research and development. This attention to chemical detail ensures that your synthesis and quality control processes are built on a foundation of precisely characterized materials.
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