In the realm of fine chemicals and pharmaceutical intermediates, 3-(2-Bromoacetyl)-5-chlorothiophene-2-sulfonamide (CAS 160982-11-6) stands out as a compound of significant importance, primarily due to its role in the synthesis of Brinzolamide. This article provides an in-depth look at its chemical characteristics, specifications, and key applications, highlighting why sourcing it from reputable manufacturers is crucial.

The chemical structure of 3-(2-Bromoacetyl)-5-chlorothiophene-2-sulfonamide features a thiophene ring with specific functional group attachments: a bromoacetyl moiety, a chlorine atom, and a sulfonamide group. This precise molecular arrangement, with the formula C6H5BrClNO3S2 and a molecular weight of 318.60 g/mol, is engineered to facilitate efficient chemical reactions. The presence of the bromoacetyl group, known for its reactivity, makes it an excellent electrophile for nucleophilic substitution reactions, a common step in complex organic syntheses.

Key specifications often include appearance, typically described as an off-white to pale yellow powder, and a high purity level, usually ≥99%. These parameters are critical for its use in pharmaceutical manufacturing, where even minor impurities can compromise the final API’s quality. The melting point is also a crucial indicator of purity and structural integrity, often falling within the range of 177-181°C.

The primary application of 3-(2-Bromoacetyl)-5-chlorothiophene-2-sulfonamide is as a direct intermediate in the synthesis pathway of Brinzolamide. Brinzolamide, an important carbonic anhydrase inhibitor, is essential for managing elevated intraocular pressure associated with open-angle glaucoma and ocular hypertension. The successful synthesis of Brinzolamide relies heavily on the quality and availability of this precursor.

For R&D scientists and production managers, identifying reliable sources for this compound is paramount. When you buy 3-(2-Bromoacetyl)-5-chlorothiophene-2-sulfonamide, it’s essential to partner with a manufacturer or supplier that guarantees consistent quality and adherence to strict manufacturing standards. Companies looking for competitive pricing and dependable delivery from a supplier in China can find value in established chemical suppliers.

Furthermore, understanding storage conditions is vital for maintaining the compound's stability. It should be stored in a cool, dry, well-closed container, protected from moisture and strong light or heat. This ensures its reactivity and purity are preserved until use in your synthesis processes.

In conclusion, the chemical properties and specific application of 3-(2-Bromoacetyl)-5-chlorothiophene-2-sulfonamide make it a vital component in the pharmaceutical industry. Ensuring access to a high-quality, reliably supplied intermediate is key to successful Brinzolamide production. We invite you to enquire about our product and how we can support your manufacturing needs.