For research and development scientists pushing the boundaries of chemical innovation, access to versatile and reactive building blocks is essential. 4-Bromo-1-butanol (CAS: 33036-62-3) is a prime example of such a compound, offering a unique combination of functional groups that make it invaluable in organic synthesis. Its specific chemical properties and reactivity profile enable its use in a wide range of applications, from crafting intricate pharmaceutical scaffolds to developing novel functional materials. Understanding these aspects is key for scientists looking to leverage its potential in their work. As a supplier dedicated to the R&D community, NINGBO INNO PHARMCHEM CO.,LTD. provides high-purity 4-Bromo-1-butanol to fuel scientific discovery.

Key Chemical Properties and Reactivity

4-Bromo-1-butanol is a bifunctional molecule, featuring a primary alcohol (-OH) and a primary alkyl bromide (-Br) group separated by a three-carbon chain. This structure dictates its chemical behavior:

• Nucleophilic Substitution at Bromine: The carbon atom bonded to bromine is electrophilic, making it susceptible to attack by nucleophiles. This allows for the facile introduction of various groups, such as amines, thiols, or other carbon chains, through SN2 reactions. This is a primary route for synthesizing new derivatives.
• Reactions of the Hydroxyl Group: The alcohol functionality can undergo typical reactions like esterification, etherification, oxidation to an aldehyde or carboxylic acid, or conversion to other leaving groups.
• Intramolecular Cyclization: Under certain basic conditions, the alcoholate anion can displace the bromide, leading to the formation of tetrahydrofuran (THF). This side reaction needs to be considered and controlled during synthesis.
• Physical Characteristics: As noted, it is typically a pale yellow to yellow liquid with a low flash point (7°C), indicating flammability, and a boiling point of 56-58°C. Its refractive index is around 1.479-1.5035. It is sensitive to moisture and light, necessitating proper storage conditions (e.g., in a cool, ventilated place, or even at -20°C for long-term stability) to maintain assay and prevent degradation.

Applications in Research and Development

The dual reactivity of 4-Bromo-1-butanol makes it a powerful tool for R&D scientists:

• Synthesis of Pharmaceutical Intermediates: Its ability to react with nitrogen-containing nucleophiles makes it ideal for creating amine-containing heterocycles, which are common structural motifs in many pharmaceuticals. Researchers often buy 4-Bromo-1-butanol for its role in building complex drug candidates.
• Creation of Specialty Polymers: It can be incorporated into monomers or used as a chain extender/modifier in polymer synthesis, introducing functionalizable bromine or hydroxyl groups into the polymer backbone or side chains.
• Development of Novel Materials: Scientists use it as a starting material for synthesizing custom organic molecules for applications in materials science, such as organic electronics or specialized coatings.
• Protective Group Chemistry: Its reaction with dihydropyran to form tetrahydropyranyl ethers is a standard method for protecting hydroxyl groups during multi-step organic syntheses. This is a frequent operation in academic research labs and process development.

Sourcing for Your Research Needs

For scientists requiring 4-Bromo-1-butanol for their research, selecting a supplier that offers consistent quality and accessible quantities is crucial. NINGBO INNO PHARMCHEM CO.,LTD. understands the demands of R&D. We offer 4-Bromo-1-butanol with assured assay and purity, available in various pack sizes suitable for laboratory use. Whether you need a small quantity for initial screening or larger amounts for scale-up studies, we are your reliable partner. Contact us to get a quote and ensure your research projects have access to this vital organic building block.