For professionals involved in chemical synthesis, a thorough understanding of a compound's properties and safe handling procedures is crucial. 2-Hydroxy-5-nitropyridine (CAS 5418-51-9) is a versatile intermediate widely used in pharmaceutical and agrochemical applications. This article provides insights into its key chemical characteristics, recommended handling practices, and storage conditions, essential knowledge for anyone looking to purchase or utilize this compound.

Chemical Profile of 2-Hydroxy-5-Nitropyridine

2-Hydroxy-5-nitropyridine, appearing as a light yellow to light brown crystalline powder, possesses a molecular formula of C5H4N2O3 and a molecular weight of 140.1. Its chemical structure is characterized by a pyridine ring substituted with a hydroxyl group at the 2-position and a nitro group at the 5-position. This arrangement imparts specific reactivity, making it a valuable intermediate in various synthetic pathways.

Key physical and chemical properties often specified include:

• Appearance: Light yellow to light brown crystalline powder.
• Purity: Typically ≥ 99.0% (often determined by HPLC).
• Melting Point: Reported in the range of 176-184°C or 188-191°C, indicating good thermal stability.
• Solubility: Soluble in hot water and alkali liquor, but generally insoluble in most organic solvents, with slight solubility in DMSO and very slight solubility in methanol.

These properties highlight its suitability for use in various reaction conditions common in organic synthesis and pharmaceutical development.

Safe Handling and Storage Recommendations

When working with 2-Hydroxy-5-nitropyridine, adhering to safety protocols is paramount. As an irritant, appropriate protective measures should be taken:

• Personal Protective Equipment (PPE): Always wear suitable protective clothing, gloves, and eye/face protection. This includes chemical-resistant gloves, safety goggles, and a lab coat.
• Ventilation: Handle the compound in a well-ventilated area or under a fume hood to minimize inhalation of dust or vapors.
• Inhalation and Skin Contact: Avoid breathing dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wash skin thoroughly after handling.
• Storage: Store the compound in a cool, dry, and well-ventilated place, away from sources of fire, heat, and direct light. It should also be kept separate from incompatible materials such as strong acids and food items. Storing under an inert atmosphere and at room temperature is often recommended for maintaining its stability.

Purchasing 2-Hydroxy-5-Nitropyridine

When you intend to buy 2-Hydroxy-5-nitropyridine, it is crucial to source it from a reliable manufacturer or supplier who provides comprehensive safety data and product specifications. Understanding these handling guidelines will ensure that you can utilize this valuable intermediate effectively and safely in your research or production processes. We are a dedicated supplier offering high-purity 2-Hydroxy-5-nitropyridine, complete with essential documentation for safe and effective use. Contact us to learn more or to request a quote.