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The Chemical Properties and Handling of 3-Picoline (CAS 108-99-6)

3-Picoline, identified by CAS number 108-99-6, is a heterocyclic organic compound with a pyridine ring substituted by a methyl group at the 3-position. Its chemical properties are critical for its diverse applications as a synthesis intermediate and solvent. Understanding these properties, along with its safety and handling requirements, is essential for manufacturers, formulators, and end-users. As a professional chemical supplier, NINGBO INNO PHARMCHEM CO.,LTD. emphasizes the importance of detailed product knowledge for safe and effective utilization.

Physically, 3-Picoline is typically described as a clear, light yellow liquid. It possesses a distinct, somewhat unpleasant odor characteristic of pyridine derivatives. Key physical properties include a boiling point of approximately 144°C and a melting point around -19°C. Its density is close to that of water, around 0.957 g/mL at 25°C. Crucially, it is soluble in water in all proportions and miscible with many common organic solvents, which enhances its utility as a reaction medium. Its flash point is around 36°C, classifying it as a flammable liquid, and requiring careful handling to prevent ignition hazards.

Chemically, 3-Picoline is a basic compound due to the nitrogen atom in the pyridine ring, readily forming salts with acids. It is also reactive and can undergo various substitution and oxidation reactions, which are leveraged in its use as a synthesis intermediate. For example, its oxidation is a key step in producing nicotinic acid. While stable under recommended storage conditions, it is incompatible with strong oxidizing agents and strong acids, as these can lead to hazardous reactions. Proper storage in ventilated, cool, and dry areas, away from incompatible materials, is imperative.

Safety considerations are paramount when handling 3-Picoline. It is classified as harmful if swallowed, inhaled, or absorbed through the skin, and can cause irritation or burns to the skin, eyes, and respiratory tract. Therefore, appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles, and protective clothing, should always be worn. Adequate ventilation or respiratory protection is necessary when working with vapors. In case of spills or exposure, immediate first aid measures as outlined in the Safety Data Sheet (SDS) must be followed.

As a dedicated manufacturer and supplier of 3-Picoline (CAS 108-99-6), we provide comprehensive technical data and safety information to our clients. We encourage all potential buyers to thoroughly review the product's SDS before use. Understanding these chemical and safety aspects ensures efficient, safe, and effective utilization of 3-picoline in your processes. For those looking to buy 3-picoline and requiring detailed technical support, our team is ready to assist. Inquire about our competitive pricing and reliable supply from our China-based operations.

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