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Polyinosinic:Polycytidylic Acid (Poly I:C), identified by its CAS number 24939-03-5, is a synthetic double-stranded RNA (dsRNA) molecule that plays a pivotal role in immunological research. Its unique chemical structure and properties are fundamental to its function as a potent Toll-like Receptor 3 (TLR3) agonist, mimicking viral dsRNA and triggering innate immune responses. Understanding these chemical characteristics is crucial for researchers aiming to optimize its application and ensure experimental reproducibility.
Chemically, Poly I:C is a complex of two homoribonucleotides: polyinosinic acid and polycytidylic acid. When these two strands anneal, they form a double-helical structure that is highly resistant to degradation by cellular RNases, though stability can be influenced by factors like pH and the presence of divalent cations. This structural integrity allows it to persist long enough within the cellular environment to engage with its target receptor, TLR3.
The molecular formula for the repeating units is approximately (C10H10N4O7P)x • (C9H11N3O7P)x, with a molecular weight of around 671.40. This large, polymeric nature contributes to its biological activity. Its solubility is generally good in aqueous solutions, particularly at physiological salt concentrations. However, improper handling or reconstitution can lead to denaturation or aggregation, compromising its efficacy. Therefore, when you buy Poly I:C, it's important to follow storage and reconstitution guidelines provided by the Poly I:C supplier.
Storage conditions are critical for maintaining the integrity of Poly I:C. It is typically stored at low temperatures (e.g., -20°C or -80°C) as a lyophilized powder to prevent degradation. When preparing stock solutions, it is often recommended to use sterile, nuclease-free water or a suitable buffer and to aliquot the solution to avoid repeated freeze-thaw cycles, which can destabilize the dsRNA structure.
The specific chemical properties of Poly I:C make it an ideal tool for simulating viral infections in vitro and in vivo, activating immune cells, and serving as a vaccine adjuvant. Researchers looking to leverage these properties should seek out a reliable Poly I:C manufacturer. We are a leading Poly I:C manufacturer in China, offering high-purity Polyinosinic:Polycytidylic Acid with detailed chemical specifications. If you need to purchase Poly I:C for your research, contact us to learn more about our product quality, Poly I:C price, and reliable supply chain.
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