For chemists and researchers involved in organic synthesis, understanding the detailed properties and synthesis routes of key intermediates is crucial for successful project execution. 1-Bromo-3-iodobenzene (CAS 591-18-4) is one such compound, valued for its unique reactivity. This article provides an in-depth look at its chemical characteristics, common synthesis pathways, and essential handling information, alongside guidance for procurement from reliable manufacturers.

Chemical Properties of 1-Bromo-3-iodobenzene

1-Bromo-3-iodobenzene, with the molecular formula C6H4BrI and a molecular weight of approximately 282.90 g/mol, is characterized by its physical appearance: a clear, colorless to light yellow liquid. Key chemical properties include:

• Melting Point: It has a low melting point, typically around -9.3 °C, indicating it remains liquid at standard room temperatures.
• Boiling Point: Its boiling point is approximately 120 °C at 18 mm Hg pressure.
• Density: The density is around 2.219 g/mL at 25 °C.
• Solubility: It shows limited solubility in water but is soluble in organic solvents like chloroform and ethyl acetate.
• Light Sensitivity: This compound is noted to be light-sensitive, requiring storage in dark conditions.
• Reactivity: The presence of both bromine and iodine atoms allows for selective reactivity in various chemical transformations, particularly in metal-catalyzed cross-coupling reactions. It can react with strong oxidizing agents, strong bases, and strong acids.

Synthesis Methods and Considerations

The synthesis of 1-Bromo-3-iodobenzene typically involves specific organic transformation methods. One common route, as detailed in scientific literature, might involve the iodination of 3-bromobenzoic acid or related precursors under specific catalytic conditions. For instance, reactions might utilize reagents such as N-iodosuccinimide (NIS) and iodine in the presence of catalysts and solvents like 1,2-dichloroethane. The process often requires careful control of reaction parameters, including temperature, inert atmosphere, and exclusion of moisture, as the reaction can be sensitive to water, significantly impacting yield.

A typical synthesis might involve steps like:

1. Precursor Preparation: Starting with a suitably substituted benzene derivative.
2. Halogenation (Iodination/Bromination): Introducing the iodine and bromine atoms at the desired meta positions. This often requires specific directing groups or catalysts.
3. Purification: After synthesis, the crude product is typically purified using techniques such as column chromatography to achieve the required purity for its intended applications.

Handling, Storage, and Safety

Due to its light sensitivity, 1-Bromo-3-iodobenzene should be stored in dark, well-sealed containers at room temperature. As an irritant, appropriate personal protective equipment (PPE) such as gloves, safety glasses, and lab coats should be worn when handling. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Adequate ventilation or use within a fume hood is recommended. Compatibility with strong oxidizing agents, bases, and acids should be avoided.

Sourcing 1-Bromo-3-iodobenzene (CAS 591-18-4)

For researchers and industrial buyers, sourcing high-quality 1-Bromo-3-iodobenzene is essential. We, as a dedicated supplier, ensure reliable availability and purity. When looking to buy this chemical, consider partnering with experienced manufacturers who offer:

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As a leading manufacturer and supplier, we are committed to providing 1-Bromo-3-iodobenzene (CAS 591-18-4) that meets stringent quality standards. Contact us today to inquire about pricing, availability, and to place your order for this vital synthetic intermediate.