For chemists, process engineers, and R&D scientists, a deep understanding of a chemical compound's properties and synthesis is fundamental to its effective application and procurement. 2-Maleimidoacetic Acid (CAS 25021-08-3) is a molecule of significant interest due to its dual functionality, enabling its use in diverse chemical processes. NINGBO INNO PHARMCHEM CO.,LTD., a leading manufacturer and supplier in China, provides this compound and insights into its chemical nature and production.

The chemical identity of 2-Maleimidoacetic Acid is characterized by its molecular formula C6H5NO4 and a molecular weight of 155.11 g/mol. It typically presents as a white to off-white crystalline powder. Key physical properties include a melting point around 114-118 °C and solubility in solvents like DMSO and methanol. The presence of both a maleimide ring and a carboxylic acid group confers its remarkable reactivity. The maleimide group is highly susceptible to nucleophilic attack, particularly by thiols, forming stable thioether linkages. This makes it an excellent reagent for Michael addition reactions, a cornerstone of its utility in bioconjugation and polymer chemistry.

The synthesis of 2-Maleimidoacetic Acid often involves reactions that build the maleimide ring and attach the acetic acid moiety. While specific proprietary methods vary among manufacturers, common routes involve precursors like maleic anhydride derivatives and glycine or its derivatives. One described synthesis involves reacting a maleimide precursor with phenyl 4-nitrilotrifluoroacetate and triethylamine in dichloromethane, followed by work-up and recrystallization to achieve the desired purity. For procurement specialists looking to buy 2-Maleimidoacetic Acid, understanding these synthesis routes can provide assurance of product origin and quality control measures employed by the manufacturer.

When sourcing this chemical, it is vital to consider the price and supply chain reliability. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing competitive pricing for high-purity 2-Maleimidoacetic Acid. Our efficient manufacturing processes and established logistics network ensure that we can reliably supply this essential intermediate to clients across various industries. We understand the importance of timely delivery and consistent product quality for your research and production needs.

The applications stemming from its chemical properties are extensive. As a bioconjugation reagent, it is indispensable for creating linkages in protein labeling, antibody-drug conjugates, and diagnostic assays. In pharmaceutical synthesis, it acts as a critical building block for complex APIs. Furthermore, its utility extends to material science, where it can be used to functionalize polymers and create novel materials with specific properties. Whether you are engaged in cutting-edge research or large-scale production, partnering with a reputable supplier like NINGBO INNO PHARMCHEM CO.,LTD. for your 2-Maleimidoacetic Acid needs is paramount for success. We invite you to purchase this versatile chemical from us and experience the difference that quality and expertise make.