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In the realm of fine chemicals and pharmaceutical intermediates, understanding the intrinsic properties and synthesis pathways of a compound is crucial for its effective utilization. 6-Bromo-3H-isobenzofuran-1-one (CAS 19477-73-7) is a noteworthy example, serving as a valuable building block in organic chemistry. This article explores its key chemical properties and discusses common methods for its synthesis, providing insights for researchers and chemists looking to buy or work with this intermediate.
The molecular formula of 6-Bromo-3H-isobenzofuran-1-one is C8H5BrO2, with a molecular weight of approximately 213.03 g/mol. It is characterized by a white to off-white crystalline powder appearance. The compound's structure features a bromo-substituted benzene ring fused to a furanone ring, forming a lactone structure. This unique combination of functional groups imparts distinct reactivity, making it a versatile intermediate. Key synonyms include 6-bromophthalide and 6-bromo-1,3-dihydro-1-isobenzofuranone.
Its chemical properties include a melting point typically in the range of 99-101°C, and it exhibits slight solubility in common organic solvents like chloroform and methanol. While detailed boiling point information is less consistently reported for such intermediates, predicted values suggest a high boiling point, indicative of its stability at ambient temperatures. For chemists seeking to purchase this compound, a reliable manufacturer will provide precise specifications regarding purity, often exceeding 98% via HPLC analysis.
The synthesis of 6-Bromo-3H-isobenzofuran-1-one often involves the bromination of suitable precursors or transformations of related phthalic acid derivatives. One common synthetic route starts from 6-aminoisobenzofuran-1(3H)-one. Through a Sandmeyer-type reaction, the amino group is diazotized and subsequently replaced with a bromine atom using copper(I) bromide (CuBr) in the presence of hydrobromic acid (HBr). This method is efficient and yields the desired product in good quantities. Researchers often rely on experienced chemical suppliers from China for access to this intermediate, benefiting from both quality and favorable price points.
Understanding these properties and synthesis methods is vital for researchers and procurement managers alike. Whether you are a medicinal chemist looking for novel drug scaffolds or an industrial chemist scaling up production, sourcing high-quality 6-Bromo-3H-isobenzofuran-1-one from a reputable supplier is key to successful outcomes. When exploring options to buy this compound, always look for detailed product information and a commitment to quality assurance from the manufacturer.
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