The intricate field of chemical synthesis is the backbone of numerous industries, particularly pharmaceuticals and fine chemicals. (aR)-4-Chlorophenylglycine Hydrochloride, identified by CAS 108392-76-3, is a compound that exemplifies this importance. This article explores its synthesis, its role in various industrial applications, and the significance of its production by leading manufacturers.

The chemical name, Benzeneacetic acid, a-amino-4-chloro-, hydrochloride(1:1),( 57187535,aR)-, clearly defines its structure: a benzeneacetic acid derivative with a chloro substituent at the para position and an alpha-amino group, presented as a hydrochloride salt. The (aR) designation underscores its specific stereochemistry, a feature critical for its biological activity and utility in synthesizing chiral drugs. Producing this compound with high purity (≥99%) requires sophisticated synthesis techniques and rigorous quality control measures.

While the specific detailed synthesis routes are often proprietary, the production of such alpha-amino acid derivatives typically involves several key steps. These may include the introduction of the amino group through amination reactions, chlorination of the phenyl ring, and controlled resolution or asymmetric synthesis to achieve the desired (aR) stereochemistry. The final step involves forming the hydrochloride salt, which enhances stability and handling properties. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. invest heavily in research and development to optimize these synthesis pathways, ensuring efficient production and high yields of the target compound.

The industrial applications of (aR)-4-Chlorophenylglycine Hydrochloride are predominantly centered within the pharmaceutical sector. It serves as a crucial intermediate in the synthesis of a wide array of Active Pharmaceutical Ingredients (APIs). Its presence in the synthetic route of certain medications makes it an indispensable component for drug manufacturers. The chloro-benzeneacetic acid moiety provides a versatile platform for building more complex molecular structures, while the amino acid functionality offers reactive sites for peptide couplings or other derivatizations.

Beyond direct API synthesis, this compound can also be valuable in drug discovery research. Medicinal chemists often utilize such well-defined building blocks to create libraries of potential drug candidates, exploring structure-activity relationships. The ability to buy alpha-amino-4-chloro-benzeneacetic acid hydrochloride with guaranteed stereochemical purity allows researchers to investigate the specific pharmacological effects of the (R)-enantiomer with confidence.

The global supply of this chemical is significant, with many manufacturers, especially in China, contributing to its availability. NINGBO INNO PHARMCHEM CO.,LTD., as a prominent supplier, plays a key role in meeting the international demand for high-quality intermediates. Their commitment to quality and extensive production capacity ensures that the pharmaceutical industry has consistent access to this vital raw material. As the pharmaceutical landscape evolves, the importance of such precisely engineered chemical intermediates will continue to grow, driving innovation and the development of life-saving medications.