Allyloxycarbonyl Succinimidyl Ester (Aloc-OSu), cataloged under CAS 135544-68-2, is a molecule of significant interest in synthetic chemistry. Its chemical structure, C8H9NO5, combines the reactivity of an N-hydroxysuccinimide ester with the protective and cleavable nature of the allyloxycarbonyl (Aloc) group. This strategic combination makes Aloc-OSu a highly versatile building block, facilitating complex synthetic pathways in various disciplines, from pharmaceuticals to advanced materials.

At its core, the N-hydroxysuccinimide (NHS) ester portion of Aloc-OSu is an activated ester. This means it is highly susceptible to nucleophilic attack, particularly from primary amines. This reactivity is the cornerstone of its utility in peptide synthesis. When Aloc-OSu reacts with an amine, it forms a stable amide bond, releasing N-hydroxysuccinimide as a byproduct. This reaction is efficient and often proceeds under mild conditions, making it ideal for the delicate process of peptide chain elongation.

The allyloxycarbonyl (Aloc) group provides a key protecting function. It shields the amine it is attached to, preventing unwanted side reactions during synthesis. What makes the Aloc group particularly valuable is its selective deprotection mechanism. It can be removed under relatively mild conditions, typically using transition metal catalysts like palladium complexes, often in the presence of a scavenger. This orthogonality allows for selective deprotection in the presence of other protecting groups, a crucial aspect of complex molecule synthesis.

The combination of these features makes Aloc-OSu a premier choice for the synthesis of glycopeptide scaffolds. These molecules mimic the glycosylated peptides found in nature and are vital for understanding biological signaling and developing new drugs. Furthermore, Aloc-OSu serves as a precursor for synthesizing functional cyclic carbonate monomers. These monomers can then be polymerized, leading to the creation of novel polymers with tailor-made properties for various industrial applications.

For research institutions and chemical companies, sourcing high-quality Aloc-OSu is essential. Manufacturers in China are prominent suppliers, often offering products with a high purity of 95% by HPLC. If you are looking to buy Allyloxycarbonyl Succinimidyl Ester for your laboratory or production needs, we are a reliable manufacturer and supplier. We invite you to request a quote for CAS 135544-68-2 and discover how our commitment to quality can support your innovative chemical synthesis projects.