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The Chemistry and Therapeutic Applications of Xanthinol Nicotinate (CAS 437-74-1)

Xanthinol Nicotinate, with CAS number 437-74-1, is a complex chemical entity that has found a critical niche in the pharmaceutical industry as a vasodilator. Its molecular formula, C19H26N6O6, hints at its intricate structure, which allows it to exert beneficial effects on blood circulation. As a pharmaceutical intermediate, it serves as a building block for medications designed to treat conditions characterized by poor blood flow.

The primary therapeutic application of Xanthinol Nicotinate lies in its ability to improve peripheral vascular diseases and cerebrovascular disorders. It functions by expanding the small arteries, thereby reducing resistance within the vascular system and leading to increased blood flow. This action is crucial for conditions like intermittent claudication, where insufficient blood supply to the limbs causes pain and limits mobility. The vasodilatory effect also benefits the brain, potentially improving cognitive functions by enhancing blood supply and nutrient delivery.

From a chemical standpoint, Xanthinol Nicotinate is a compound formed from a xanthine derivative and nicotinic acid. This combination allows it to provide a dual benefit: the xanthine component aids in arterial dilation, while the nicotinic acid component influences cellular metabolism, improving the utilization of glucose and oxygen. This dual action is particularly valuable in addressing the complex pathologies of vascular diseases. The availability of Xanthinol Nicotinate as a high-purity powder facilitates its use in various pharmaceutical formulations.

The significance of Xanthinol Nicotinate as a chemical raw powder lies in its purity and consistent quality, essential for pharmaceutical-grade ingredients. Manufacturers specializing in pharmaceutical intermediates often highlight the assay of their products, typically around 99% or higher for Xanthinol Nicotinate. This emphasis on purity ensures that the final drug product is safe and effective, meeting rigorous regulatory standards. Sourcing this API requires careful consideration of supplier qualifications and adherence to GMP standards.

In summary, Xanthinol Nicotinate (CAS 437-74-1) is a chemically significant pharmaceutical intermediate. Its vasodilatory and metabolic-enhancing properties make it a valuable therapeutic agent for improving blood circulation in both the periphery and the brain. Its availability as a high-purity powder makes it an indispensable component in the development of treatments for a range of vascular and circulatory health issues.

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