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The Chemistry Behind Daclatasvir: A Look at Key Intermediates

The development of effective treatments for chronic Hepatitis C virus (HCV) infections has been a remarkable achievement in modern medicine. Daclatasvir, a potent NS5A inhibitor, has played a pivotal role in this advancement. The journey from raw materials to the final life-saving drug involves a sophisticated series of chemical transformations, with specific pharmaceutical intermediates acting as crucial linchpins. One such indispensable compound is tert-Butyl (2S)-2-[5-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carboxylate (CAS: 1007882-12-3).

This complex molecule serves as a foundational building block in the multi-step synthesis of Daclatasvir. Its intricate structure, incorporating a tert-butyl protected pyrrolidine ring, an imidazole core, and a phenylboronic ester moiety, is precisely engineered to facilitate subsequent coupling reactions. The boronic ester group, in particular, is highly reactive in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern organic synthesis, enabling the precise assembly of the final Daclatasvir molecule. For researchers and chemical engineers involved in drug development, understanding the synthesis and sourcing of such intermediates is paramount.

As a leading manufacturer and supplier of high-purity pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing critical components like tert-Butyl (2S)-2-[5-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carboxylate. We ensure that our product meets rigorous specifications, including an assay of ≥98.0%, guaranteeing its suitability for demanding pharmaceutical applications. Our commitment to quality control and efficient production processes means that when you choose us, you are investing in the reliability and success of your Daclatasvir production. We understand the importance of consistent supply, and we actively work to provide our global clients with the materials they need, when they need them.

Procurement specialists and R&D scientists often search for terms such as 'buy tert-Butyl (2S)-2-[5-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carboxylate' or 'Daclatasvir intermediate price'. NINGBO INNO PHARMCHEM CO.,LTD. aims to be the go-to source for these inquiries. We pride ourselves on offering competitive prices for high-quality pharmaceutical intermediates, supported by robust technical data and customer service. Whether you are conducting early-stage research or scaling up for commercial manufacturing, our capabilities as a trusted supplier in China are designed to meet your needs. Explore the advantages of partnering with a specialist manufacturer committed to advancing pharmaceutical synthesis.

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NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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WHY CHOSE US?

1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;

2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;

3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

FAQ

  • A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.

  • A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.

  • A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.

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Should you need to contact us; you may call during regular business hours, Monday through Friday, 8am – 6 pm.
NINGBO INNO PHARMCHEM CO.,LTD.
Address: No.163 Ruiqing Rd.,Ningbo 315000 China
Phone: 86-574-87319282
Fax: 86-574-27912196
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