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The chromen-4-one (or benzopyran-4-one) scaffold is a fundamental structural motif found in a vast array of naturally occurring compounds and synthetic molecules exhibiting significant biological activities. Its versatility makes it a prime target for medicinal chemists aiming to develop new therapeutic agents. NINGBO INNO PHARMCHEM CO.,LTD. contributes to this field by supplying key intermediates like 8-Amino-2-(2H-tetrazol-5-yl)chromen-4-one hydrochloride (CAS 110683-23-3), which features this important core structure.
The chromen-4-one ring system is characterized by a benzene ring fused to a pyran-4-one ring. This bicyclic structure provides a rigid framework that can be readily functionalized at various positions, allowing for the fine-tuning of physicochemical and biological properties. The specific compound, 8-Amino-2-(2H-tetrazol-5-yl)chromen-4-one hydrochloride, incorporates an amino group at the 8th position and a tetrazol-5-yl group at the 2nd position of the chromen-4-one core. This unique combination of functionalities makes it a valuable intermediate, particularly in the synthesis of pharmaceuticals like ranlukast.
The ability to buy 8-Amino-2-(2H-tetrazol-5-yl)chromen-4-one hydrochloride with high purity (≥99.0%) from a reliable pharmaceutical intermediates supplier like NINGBO INNO PHARMCHEM CO.,LTD. is crucial for researchers and manufacturers. The specific arrangement of the amino and tetrazole groups on the chromen-4-one backbone is critical for its intended use in the synthesis of ranlukast, a drug used for treating asthma. The precise understanding and manipulation of the chemical properties of 8-Amino-2-(2H-tetrazol-5-yl)chromen-4-one hydrochloride are paramount for the successful development of such APIs.
Medicinal chemists often explore variations of existing scaffolds to discover new drug candidates with improved efficacy, safety profiles, or novel mechanisms of action. The chromen-4-one framework offers a rich platform for such exploration, and intermediates like the one discussed here provide ready access to this valuable chemical space. The consistent availability and competitive price of 8-Amino-2-(2H-tetrazol-5-yl)chromen-4-one hydrochloride further facilitate research and development efforts in this area.
NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supporting advancements in medicinal chemistry by providing high-quality, well-characterized chemical intermediates. By supplying compounds that incorporate important structural motifs like the chromen-4-one scaffold, the company plays an essential role in the development of innovative therapies that address unmet medical needs. The ongoing exploration of chromen-4-one derivatives promises exciting new avenues in drug discovery.
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