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Dibenz[b,e]oxepin-11(6H)-one, identified by CAS number 4504-87-4, is a compound of significant interest within the pharmaceutical and fine chemical industries. Its molecular formula, C14H10O2, and molecular weight of 210.23 g/mol, hint at its structural complexity and utility in organic synthesis.
Chemically, Dibenz[b,e]oxepin-11(6H)-one is often described as a pale yellow solid. Its physical properties, such as melting point (typically in the range of 68-72°C) and solubility (slightly soluble in solvents like chloroform, ethyl acetate, and methanol), are important considerations for handling, storage, and reaction planning in a laboratory or manufacturing setting. These characteristics allow for its effective purification and incorporation into various synthetic routes.
The primary significance of Dibenz[b,e]oxepin-11(6H)-one lies in its role as a crucial pharmaceutical intermediate. It is particularly recognized for its application in the synthesis of doxepin, a tricyclic antidepressant drug widely used for treating depression, anxiety, and insomnia. The specific chemical structure of Dibenz[b,e]oxepin-11(6H)-one provides a foundational scaffold that can be further modified to achieve the final doxepin molecule.
Beyond its direct use in API synthesis, Dibenz[b,e]oxepin-11(6H)-one is also identified as a photodecomposition product of doxepin. This characteristic makes it valuable in pharmaceutical stability studies, helping researchers understand how doxepin might degrade under various environmental conditions, particularly light exposure.
The synthesis of Dibenz[b,e]oxepin-11(6H)-one itself typically involves multi-step organic reactions. While specific patented routes vary, common strategies might involve cyclization reactions of appropriately substituted diphenyl ethers or related aromatic compounds. Manufacturers often optimize these synthesis pathways to achieve high yields and purity, ensuring the compound is readily available for procurement by the pharmaceutical sector.
For companies requiring this intermediate, partnering with reputable chemical manufacturers, especially those based in China, is a strategic move. These suppliers often possess the expertise and infrastructure to produce Dibenz[b,e]oxepin-11(6H)-one at scale, with strict quality controls in place. When you need to buy Dibenz[b,e]oxepin-11(6H)-one, prioritizing suppliers who can guarantee its chemical integrity and provide comprehensive technical data is key to a successful research and development or manufacturing project.
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