For researchers and development scientists, understanding the chemical properties and synthesis pathways of key intermediates is crucial for innovation. Pyridine-3-sulfonyl Chloride Hydrochloride (CAS 16133-25-8) is a compound of significant interest, serving as a versatile reagent in organic synthesis and a vital intermediate in the pharmaceutical industry. This article explores its chemistry, applications, and how to effectively source it for your research and development needs.

Chemical Profile: Pyridine-3-sulfonyl Chloride Hydrochloride

Pyridine-3-sulfonyl Chloride Hydrochloride (CAS 16133-25-8) is an organic compound characterized by its pyridine ring functionalized with a sulfonyl chloride group. The hydrochloride salt form enhances its stability and handling properties. Its molecular formula is C5H4ClNO2S, with a molecular weight of approximately 177.61 g/mol. Typically appearing as a white powder, its reactive sulfonyl chloride moiety makes it a potent acylating agent and a key building block for creating more complex organic molecules.

Synthesis and Chemical Reactivity

While specific industrial synthesis routes can vary, the preparation of pyridine-3-sulfonyl chloride often involves the conversion of corresponding sulfonic acids or their salts. The sulfonyl chloride group is highly electrophilic, readily reacting with nucleophiles such as amines, alcohols, and thiols to form sulfonamides, sulfonates, and thioesters, respectively. This reactivity is fundamental to its utility as an intermediate in creating diverse chemical structures. Researchers often utilize it in reactions requiring the formation of sulfonyl linkages.

Key Applications in Research and Development

The primary application of Pyridine-3-sulfonyl Chloride Hydrochloride (CAS 16133-25-8) is in the synthesis of pharmaceutical compounds. Its role as an intermediate in the production of vonoprazan fumarate, a drug targeting acid-related disorders, is well-documented. Beyond this specific use, its reactivity makes it valuable for R&D scientists in:

• Medicinal Chemistry: Synthesizing novel drug candidates by introducing the 3-pyridinesulfonyl moiety into potential therapeutic agents.
• Material Science: Exploring new functional materials or polymers where sulfonamide or sulfonate linkages are desired.
• Agrochemicals: Investigating new pesticides or plant growth regulators that incorporate pyridine or sulfonyl functional groups.

Procurement for R&D: What to Look For

For R&D professionals needing to buy Pyridine-3-sulfonyl Chloride Hydrochloride, sourcing from reliable suppliers is crucial. Key factors include:

• Purity and Consistency: Ensuring high purity (e.g., 98%+) and batch-to-batch consistency is vital for reproducible research results.
• Supplier Reputation: Opt for suppliers with a strong track record in providing research chemicals, including those with proper documentation (CoA, MSDS).
• Availability: Having access to small to medium quantities is often necessary for initial research phases.
• Competitive Pricing: Balancing cost with quality is important, especially for academic labs or early-stage R&D projects.

Conclusion

Pyridine-3-sulfonyl Chloride Hydrochloride (CAS 16133-25-8) is a chemically significant compound with important applications in pharmaceuticals and beyond. By understanding its synthesis, reactivity, and prioritizing reliable sourcing from reputable manufacturers and suppliers, R&D scientists can effectively leverage this intermediate to drive innovation in their respective fields.