For professionals involved in chemical synthesis, understanding the intricate details of key intermediates like Z-Pro-Pro-OH is fundamental. This dipeptide derivative, known for its application in peptide synthesis and pharmaceutical development, possesses specific chemical properties that dictate its utility. As a leading manufacturer and supplier, we aim to clarify the chemistry, synthesis, and specifications of Z-Pro-Pro-OH, ensuring you can confidently buy Z-Pro-Pro-OH for your critical applications.

Chemical Identity and Properties of Z-Pro-Pro-OH

Z-Pro-Pro-OH, also referred to as carbobenzoxy-L-prolyl-L-proline, is a dipeptide formed by linking two L-proline amino acids. Its chemical structure is defined by the CAS Number 7360-23-8. The molecular formula is C18H22N2O5, resulting in a molecular weight of approximately 346.38 g/mol. The defining feature of Z-Pro-Pro-OH is the carbobenzoxy (Z) protecting group attached to the N-terminus of the first proline residue. This protecting group is crucial for peptide synthesis as it selectively blocks the amine functionality, preventing unwanted reactions during coupling steps. The presence of proline residues also contributes to unique conformational preferences within the peptide chain.

Synthesis of Z-Pro-Pro-OH

The synthesis of Z-Pro-Pro-OH typically involves established peptide coupling methodologies. Common approaches include:

• Solid-Phase Peptide Synthesis (SPPS): This method involves attaching the carboxy-terminal proline to a solid resin support, followed by deprotection of its amino group and coupling with N-Z-protected proline. This process is repeated step-by-step to build the peptide chain.
• Solution-Phase Synthesis: In this method, protected amino acids are coupled in solution. Activation of N-Z-proline, often using coupling reagents like DCC/HOBt or EDC, followed by reaction with proline, yields the desired dipeptide. This approach is often preferred for larger scale production and offers direct purification of intermediates.

As a dedicated Z-Pro-Pro-OH manufacturer, we employ optimized synthesis protocols to ensure high yield and purity. We understand that consistent quality is vital, whether you are synthesizing small peptides for research or larger batches for development.

Key Specifications for Procurement

When you intend to purchase Z-Pro-Pro-OH, understanding its specifications is key:

• Purity: High purity, typically assessed by HPLC, is critical for successful peptide synthesis. For pharmaceutical applications, purity levels of ≥98% are often standard.
• Appearance: Z-Pro-Pro-OH is generally supplied as a white to off-white solid.
• Solubility: Its solubility in common organic solvents like DMF or DMSO is an important factor for ease of use in synthesis protocols.
• Storage Conditions: Proper storage (often at 0-8°C or room temperature, protected from moisture) is necessary to maintain its integrity.

Your Reliable Z-Pro-Pro-OH Supplier

We pride ourselves on being a dependable Z-Pro-Pro-OH supplier. By manufacturing Z-Pro-Pro-OH in China, we can offer competitive pricing without compromising on quality. Our commitment extends to providing thorough documentation, including product specifications and safety data sheets, to support your procurement decisions. Whether you need small quantities for R&D or larger batches for manufacturing, we are equipped to meet your demands.

Conclusion

The chemistry of Z-Pro-Pro-OH is well-understood, making it a reliable building block for a variety of applications. By understanding its synthesis, properties, and specifications, researchers and manufacturers can make informed decisions when sourcing this essential chemical. Contact us today to explore our high-quality Z-Pro-Pro-OH and discuss your specific requirements. We are your trusted partner for advanced peptide synthesis intermediates.