Chlorhexidine Digluconate (CHG), identified by its CAS number 18472-51-0, is a widely recognized and essential chemical compound known for its potent antiseptic and disinfectant properties. This versatile biguanide derivative, with a molecular formula of C34H54Cl2N10O14 and a molecular weight of 897.76 g/mol, has been a cornerstone in medical and hygiene practices since its introduction in the 1950s. Its broad-spectrum efficacy against a diverse range of microorganisms makes it indispensable in preventing and controlling infections across various sectors.

In clinical settings, CHG plays a crucial role in maintaining sterility and preventing healthcare-associated infections. It is extensively used for skin disinfection prior to surgical procedures, significantly reducing the risk of surgical site infections. Healthcare professionals rely on CHG for effective hand antisepsis. Beyond surgical preparation, it is applied for cleaning wounds, ensuring a germ-free environment conducive to healing. Its utility extends to the maintenance of medical devices, such as preventing the blocking of urinary catheters, and has even been adopted for daily bathing of patients in intensive care units to mitigate infection risks.

Chlorhexidine Digluconate is a prominent agent in dental and oral hygiene. Formulations such as mouthwashes, gels, and sprays containing CHG are highly effective in reducing dental plaque build-up and alleviating mild gingivitis. It is also prescribed for treating various oral conditions, including mouth ulcers and yeast infections of the mouth (oral thrush). Dental professionals utilize CHG for root canal irrigation and as an intracanal dressing in endodontic procedures, highlighting its antimicrobial strength in complex dental treatments.

The powerful antimicrobial action of Chlorhexidine Digluconate stems from its cationic nature. At physiological pH, CHG dissociates to release a positively charged chlorhexidine cation. This cation then binds to the negatively charged cell walls of bacteria, disrupting their integrity. At lower concentrations, this binding leads to a bacteriostatic effect, inhibiting bacterial growth. At higher concentrations, it causes significant membrane disruption, resulting in rapid cell death. CHG is effective against a wide array of Gram-positive and Gram-negative bacteria, as well as yeasts. Chemically, it is a cationic polybiguanide that is miscible with water, ethanol, and acetone, but it is important to note that its efficacy can be compromised by anionic compounds commonly found in some detergents and toothpastes.

While Chlorhexidine Digluconate is generally safe for topical and oral short-term use, awareness of its potential side effects is important. Common side effects associated with oral use include temporary tooth discoloration, alterations in taste sensation, and skin irritation. Direct contact with eyes or ears should be avoided, as it can lead to problems, including ototoxicity if it enters a ruptured eardrum. When ingested, CHG is poorly absorbed, though it can cause stomach irritation or nausea. Prolonged use of chlorhexidine gluconate mouthwash beyond six months is generally not recommended by health authorities due to unclarified long-term effects. Adhering to proper usage instructions ensures optimal benefits and safety.

Beyond its primary medical and dental applications, Chlorhexidine Digluconate finds use as a disinfectant for hands and surfaces, an additive in various cosmetic products such as creams, toothpaste, deodorants, and antiperspirants, and as a preservative in certain pharmaceutical products like eye drops. It is also an active ingredient in specialized wound dressings and antiseptic washes. For those looking to buy Chlorhexidine Digluconate, understanding the product's specifications and the reputation of the manufacturer is crucial. As a leading supplier of high-quality chemical compounds, we ensure strict adherence to international standards. Competitive price options are available, catering to bulk purchase requirements for diverse industrial and professional applications.